| Use of intrathecal nicardipine for aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm. | |
| | |
MedLine Citation:
|
PMID: 19139684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cerebral vasospasm leading to delayed ischemia is a common and serious complication of aneurysmal subarachnoid hemorrhage that often results in increased morbidity and mortality. Treatments for cerebral vasospasm, including triple-H therapy (therapeutic hypervolemia, hypertension, and hemodilution), nimodipine, balloon angioplasty, and intra-arterial vasodilators have limitations in their efficacy and safety profiles. Nicardipine, a calcium channel blocker, is available for intravenous administration for blood pressure reduction. A recent study reported its efficacy in the treatment of cerebral vasospasm when given intrathecally (IT). We present our experiences with IT nicardipine for treatment of cerebral vasospasm. METHODS: IT nicardipine was administered to six patients with aneurysmal subarachnoid hemorrhage after prophylactic and aggressive therapeutic management for vasospasm failed. RESULTS: In these patients, IT nicardipine treatment was followed within 8 hours by a 43.1 +/- 31.0 cm/s decrease in middle cerebral arterial flow velocity, as measured by transcranial Doppler ultrasound. CONCLUSIONS: Based on these positive results, we believe that larger scale studies evaluating the safety and efficacy of IT nicardipine for the management of cerebral vasospasm are warranted. |
| | |
Authors:
|
As'ad Ehtisham; Scott Taylor; Linda Bayless; Owen B Samuels; Michael W Klein; Jeff M Janzen |
Related Documents
:
|
12805934 - Calcitonin gene-related peptide (cgrp) in cerebrovascular disease. 1467574 - Early prediction of outcome from coma. 16028764 - Delayed cell death related to acute cerebral blood flow changes following subarachnoid ... 15626454 - Delayed cerebral vasospasm and nitric oxide: review, new hypothesis, and proposed treat... 8719194 - Suppression of cerebral metabolic rate for oxygen (cmro2) by mild hypothermia compared ... 6482984 - Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intesti... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Southern medical journal Volume: 102 ISSN: 1541-8243 ISO Abbreviation: South. Med. J. Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-02-10 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
|
Languages: eng Pagination: 150-3 Citation Subset: AIM; IM |
Affiliation:
|
Neuroscience Critical Care Unit, Via Christi Regional Medical Center, University of Kansas School of Medicine, Wichita, KS 67214, USA. aehtisham@kumc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Calcium Channel Blockers / administration & dosage, therapeutic use* Female Humans Injections, Spinal Male Middle Aged Nicardipine / administration & dosage, therapeutic use* Subarachnoid Hemorrhage / complications, drug therapy* Vasospasm, Intracranial / drug therapy*, etiology |
| Chemical | |
Reg. No./Substance:
|
0/Calcium Channel Blockers; 55985-32-5/Nicardipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tracheobronchial foreign body aspiration in adults.
Next Document: New guidelines for the prevention and treatment of osteoporosis.