Document Detail


Use of intralesional interferon-alpha for the treatment of recalcitrant oral warts in patients with AIDS: a report of 4 cases.
MedLine Citation:
PMID:  11740478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four human immunodeficiency virus-positive homosexual men with 2- to 4.5-year histories of recurrent oral warts that had failed to respond to conventional surgical and other treatment modalities were offered treatment with interferon-alpha. All had multiple or large oral warts, 3 had skin warts, 2 had a history of anal warts, and 1 had penile lesions. All 4 patients were treated with a combination of intralesional and subcutaneous interferon-alpha. Adverse side effects were dose-related, mild, and transient; they included flulike symptoms (3 patients), hair loss and tachycardia (1 patient), and transient changes in the white blood cell count. All patients responded to therapy and remained free of disease up to 42 months. Intralesional injection with interferon-alpha appears to provide excellent clinical control for recurrent, multiple, and extensive oral warts in the human immunodeficiency virus-positive population, and is a useful adjunct to initial surgical removal of oral warts.
Authors:
F Lozada-Nur; M Glick; M Schubert; I Silverberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  92     ISSN:  1079-2104     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-03-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617-22     Citation Subset:  D; IM    
Affiliation:
Department of Stomatology, University of California, San Francisco 94143-0422, USA. fln@itsa.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications*
Adult
Antiviral Agents / administration & dosage*
Homosexuality, Male
Humans
Injections, Intralesional
Injections, Subcutaneous
Interferon Type I, Recombinant / administration & dosage*
Male
Middle Aged
Mouth Diseases / complications,  drug therapy*
Warts / complications*,  drug therapy*
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon Type I, Recombinant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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