Document Detail

Use of intermediate cardiovascular endpoints in intervention studies: not as easy as it seems?
MedLine Citation:
PMID:  15554594     Owner:  NLM     Status:  MEDLINE    
In the current issue of the Journal, Van den Berkmortel and coworkers' report on the effect of smoking cessation on cardiovascular risk reduction, as estimated by assessment of progression of carotid intima-media thickness (CIMT) and arterial stiffness. Much to the authors' surprise, their nonrandomised study among 33 subjects who stopped smoking for at least two years, 55 persistent smokers and 50 never-smokers showed no difference in rate of change in CIMT or arterial stiffness across the groups after two years of intervention. The intriguing question of the paper is whether the finding is true or may be attributed to potential flaws of the study, focussing on design and analytical procedures, the choice of the endpoint and the power of the study.
M L Bots
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Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  62     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-11-19     Completed Date:  2004-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  214-5     Citation Subset:  IM    
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MeSH Terms
Cardiovascular Diseases / etiology*,  pathology,  prevention & control
Disease Progression
Endpoint Determination*
Intervention Studies*
Risk Factors
Risk Reduction Behavior
Smoking / adverse effects*
Smoking Cessation*
Comment On:
Neth J Med. 2004 Jul-Aug;62(7):235-41   [PMID:  15554598 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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