| Use of in-cycle antimüllerian hormone levels to predict cycle outcome. | |
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MedLine Citation:
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PMID: 21636068 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: The goal of this work is to expand the usefulness of antimüllerian hormone (AMH) in predicting in vitro fertilization cycle outcome by demonstrating that AMH concentration obtained in an ongoing treatment cycle predicts both oocyte number and pregnancy. STUDY DESIGN: Serum samples were obtained from 190 in vitro fertilization patients at onset of follicle-stimulating hormone stimulation. These were analyzed retrospectively during a single cycle in which clinicians were blinded to the results. Our major outcome measures were the number of oocytes obtained and ongoing pregnancy. RESULTS: Patients with an initial AMH concentration of >3 ng/mL were found to produce a mean of 19.8 oocytes and had an ongoing pregnancy rate of 60.3%. In contrast, those with AMH values of ≤1 ng/mL yielded a mean of 6.2 oocytes and had an ongoing pregnancy rate of 23.4% (P < .0001 for both). CONCLUSION: Greater AMH serum concentration strongly predicts an increased number of oocytes and ongoing pregnancy (P ≤ .0001). |
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Authors:
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Andrew S Blazar; Geralyn Lambert-Messerlian; Richard Hackett; Stephan Krotz; Sandra A Carson; Jared C Robins |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: - ISSN: 1097-6868 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-6-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, RI; Divisions of Reproductive Endocrinology and Infertility, Women & Infants Hospital of Rhode Island, Providence, RI. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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