| Use of immunosuppressive agents in uveitis. | |
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MedLine Citation:
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PMID: 14615647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review summarizes current patterns in the use of immunosuppressive agents in patients with uveitis. RECENT FINDINGS: A number of immunosuppressive agents are currently available for the treatment of uveitis. Reports of safety and efficacy, although numerous, have been largely nonrandomized and performed without controls, limiting, to some extent, the strength and generalizability of their conclusions. Nonetheless, the volume of case reports and case series provides compelling evidence that immunosuppressive agents are effective at providing long-term control in patients with moderate to severe chronic or recurrent uveitis. The choice of immunosuppressive agent is complex, and depends on the cause and severity of the patient's underlying inflammation, the presence or absence of associated systemic inflammation, and the patient's prior response to immunosuppressive treatments. SUMMARY: Although corticosteroids remain the primary initial treatment for patients with uveitis, use of noncorticosteroid immunosuppressive agents in selected patients with uveitis allows for improved control and decreased risk of corticosteroid-induced side effects. |
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Authors:
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Marc J Lustig; Emmett T Cunningham |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in ophthalmology Volume: 14 ISSN: 1040-8738 ISO Abbreviation: Curr Opin Ophthalmol Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-11-17 Completed Date: 2004-07-14 Revised Date: 2006-10-13 |
Medline Journal Info:
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Nlm Unique ID: 9011108 Medline TA: Curr Opin Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 399-412 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, New York University School of Medicine, and Manhattan Eye, Ear, and Throat Hospital, New York, 10021, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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therapeutic use Antimetabolites / therapeutic use Arthritis, Juvenile Rheumatoid / complications* Biological Products / therapeutic use Cross-Linking Reagents / therapeutic use DNA / drug effects DNA-Binding Proteins / antagonists & inhibitors Humans Immunosuppressive Agents / therapeutic use* Intracellular Membranes / metabolism NF-kappa B / antagonists & inhibitors NFATC Transcription Factors Nuclear Proteins* Signal Transduction / drug effects Transcription Factors / antagonists & inhibitors Uveitis / diagnosis*, etiology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antimetabolites; 0/Biological Products; 0/Cross-Linking Reagents; 0/DNA-Binding Proteins; 0/Immunosuppressive Agents; 0/NF-kappa B; 0/NFATC Transcription Factors; 0/Nuclear Proteins; 0/Transcription Factors; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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