| Use of hydroxyurea in psoriasis. | |
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MedLine Citation:
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PMID: 10233638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydroxyurea is an effective treatment in chronic plaque psoriasis that is relatively simple to prescribe. Dose-related bone marrow toxicity is the principal side-effect of therapy although clinically significant complications are few, provided that blood counts are monitored carefully. In contrast with many other second-line agents, renal and liver disease do not necessarily preclude treatment, and there are few drug interactions likely to be of clinical relevance in dermatology. Recent studies on the use of hydroxyurea for sickle cell disease may provide more information on predicting the maximal tolerated dose and potential hazards of long-term therapy in nonmalignant disease and perhaps revive interest in the drug's use in dermatology. |
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Authors:
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C H Smith |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 24 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-07-29 Completed Date: 1999-07-29 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2-6 Citation Subset: IM |
Affiliation:
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Skin Therapy Research Unit, St John's Institute of Dermatology, London, UK. kjackson@umds.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Hydroxyurea / adverse effects, therapeutic use* Nucleic Acid Synthesis Inhibitors / adverse effects, therapeutic use* Psoriasis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acid Synthesis Inhibitors; 127-07-1/Hydroxyurea |
| Comments/Corrections | |
Comment In:
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Clin Exp Dermatol. 1999 Nov;24(6):496
[PMID:
10681171
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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