Document Detail

Use of hybrid shots in planning Perfexion Gamma Knife treatments for lesions close to critical structures.
MedLine Citation:
PMID:  19123886     Owner:  NLM     Status:  MEDLINE    
OBJECT: The authors investigated the use of different collimator values in different sectors (hybrid shots) when treating patients with lesions close to critical structures with the Perfexion model Gamma Knife. METHODS: Twelve patients with various tumors (6 with a pituitary tumor, 3 with vestibular schwannoma, 2 with meningioma, and 1 with metastatic lesion) that were within 4 mm of the brainstem, optic nerve, pituitary stalk, or cochlea were considered. All patients were treated at the authors' institution between June 2007 and March 2008. The patients' treatments were replanned in 2 different ways. In the first plan, hybrid shots were used such that the steepest dose gradient was aligned with the junction between the target and the critical structure(s). This was accomplished by placing low-value collimators in appropriate sectors. In the second plan, no hybrid shots were used. Sector blocking (either manual or dynamic) was required for all plans to reduce the critical structure doses to acceptable levels. Prescribed doses ranged from 12 to 30 Gy at the periphery of the target. The plans in each pair were designed to be equally conformal in terms of both target coverage (as measured by the Paddick conformity index) and critical structure sparing. RESULTS: The average number of shots required was roughly the same using either planning technique (16.7 vs 16.6 shots with and without hybrids). However, for all patients, the number of blocked sectors required to protect critical areas was larger when hybrid shots were not used. On average, nearly twice as many blocked sectors (14.8 vs 7.0) were required for the plans that did not use hybrid shots. The number of high-value collimators used in each plan was also evaluated. For small targets (<or= 1 cm(3)), for which 8 mm was considered a high value for the collimator, plans employing hybrids used an average of 2.3 times as many 8-mm sectors as did their nonhybrid counterparts (7.4 vs 3.2 sectors). For large targets (> 1 cm(3)), for which 16 mm was considered a high value for the collimator, hybrid plans used an average of 1.4 times as many 16-mm sectors as did the plans without hybrids (10.7 vs 7.7 sectors). Decreasing the number of blocked sectors and increasing the number of high-value collimator sectors led to use of shorter beam-on times. Beam-on times were 1-39% higher (average 17%) when hybrid shots were not allowed. The average beam-on time for plans with and without hybrid shots was 67.4 versus 78.4 minutes. CONCLUSIONS: The judicious use of hybrid shots in patients for whom the target is close to a critical structure is an efficient way to achieve conformal treatments while minimizing the beam-on time. The reduction in beam-on time with hybrid shots is attributed to a reduced use of blocked sectors and an increased number of high-value collimator sectors.
Paula L Petti; David A Larson; Sandeep Kunwar
Related Documents :
22422276 - N,n-dimethylformamide-stabilized gold nanoclusters as a catalyst for the reduction of 4...
9047366 - A 29 residue region of the sarcomeric myosin rod is necessary for filament formation.
10491176 - Mutational analysis of ser14 and asp157 in the nucleotide-binding site of beta-actin.
18945676 - Role of intermonomer ionic bridges in the stabilization of the actin filament.
8384996 - The detection and isolation of protease activity associated with purified preparations ...
3516996 - In vivo formation and stability of engineered disulfide bonds in subtilisin.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  109 Suppl     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-40     Citation Subset:  AIM; IM    
Gamma Knife Center, Taylor McAdam Bell Neuroscience Institute, Washington Hospital Healthcare System, Fremont, California 94538, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Neoplasms / pathology,  surgery*
Cohort Studies
Cranial Nerve Neoplasms / pathology,  surgery*
Equipment Design
Magnetic Resonance Imaging
Radiosurgery / instrumentation*
Radiotherapy Dosage
Reproducibility of Results
Retrospective Studies
Surgery, Computer-Assisted*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Virtual framing: the feasibility of frameless radiosurgical planning for the Gamma Knife.
Next Document:  Definition of the key target volume in radiosurgical management of arteriovenous malformations: a ne...