Document Detail

Use of human somatotrophin in the treatment of a patient with methylmalonic aciduria.
MedLine Citation:
PMID:  8529687     Owner:  NLM     Status:  MEDLINE    
Growth hormone (GH) insufficiency was demonstrated in a patient with methylmalonic aciduria. GH administration at 14-21 U/m2 per week accelerated linear growth, stimulated lipolysis, and produced clinical improvement and reduced urinary methylmalonate excretion. The clinical and metabolic benefits were lost as the dose of GH was increased to 28 U/m2 per week. CONCLUSION. The use of GH in other patients with methylmalonic aciduria (and other disorders of intermediary metabolism demonstrating similar clinical and metabolic features) warrants further study.
M D Bain; S S Nussey; M Jones; R A Chalmers
Related Documents :
370137 - The effect of methysergide, pimozide, and sodium valproate on the diazepam-stimulated g...
1934527 - Clonidine pretreatment modifies the growth hormone secretory pattern induced by short-t...
10620427 - Production of a recombinant newt growth hormone and its application for the development...
8421077 - Continuous subcutaneous infusions of growth hormone (gh) releasing hormone 1-44 for 14 ...
3345217 - Development of young rats and rabbits exposed to a strong electric field.
3009677 - Effect of testosterone on gonadotrophin-releasing hormone receptors in the castrated ra...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  154     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-01-29     Completed Date:  1996-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  850-2     Citation Subset:  IM    
Department of Child Health, St George's Hospital Medical School, London, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Metabolism, Inborn Errors / enzymology,  therapy*
Body Height / drug effects
Follow-Up Studies
Growth Hormone / deficiency,  therapeutic use*
Lipid Mobilization / drug effects
Methylmalonic Acid / urine*
Methylmalonyl-CoA Mutase / deficiency
Recombinant Proteins / therapeutic use
Reg. No./Substance:
0/Recombinant Proteins; 516-05-2/Methylmalonic Acid; 9002-72-6/Growth Hormone; EC Mutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  No reduction in birth weight in phenylketonuria.
Next Document:  Cardiopulmonary function in premature infants with bronchopulmonary dysplasia--a 2-year follow up.