| Use of human somatotrophin in the treatment of a patient with methylmalonic aciduria. | |
| | |
MedLine Citation:
|
PMID: 8529687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Growth hormone (GH) insufficiency was demonstrated in a patient with methylmalonic aciduria. GH administration at 14-21 U/m2 per week accelerated linear growth, stimulated lipolysis, and produced clinical improvement and reduced urinary methylmalonate excretion. The clinical and metabolic benefits were lost as the dose of GH was increased to 28 U/m2 per week. CONCLUSION. The use of GH in other patients with methylmalonic aciduria (and other disorders of intermediary metabolism demonstrating similar clinical and metabolic features) warrants further study. |
| | |
Authors:
|
M D Bain; S S Nussey; M Jones; R A Chalmers |
Related Documents
:
|
2676477 - A cellular basis for growth hormone deficiency in the dwarf rat: analysis of growth hor... 6835017 - Ontogeny of endocrine responses to methadone in rats. 8421077 - Continuous subcutaneous infusions of growth hormone (gh) releasing hormone 1-44 for 14 ... 2993187 - Effect of growth hormone on the activity of some lysosomal enzymes in neutrophilic poly... 2676477 - A cellular basis for growth hormone deficiency in the dwarf rat: analysis of growth hor... 20404037 - Thyroid hormone concentrations in systemic circulation and ovarian follicular fluid of ... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: European journal of pediatrics Volume: 154 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1995 Oct |
Date Detail:
|
Created Date: 1996-01-29 Completed Date: 1996-01-29 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 850-2 Citation Subset: IM |
Affiliation:
|
Department of Child Health, St George's Hospital Medical School, London, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Metabolism, Inborn Errors
/
enzymology,
therapy* Body Height / drug effects Child Female Follow-Up Studies Growth Hormone / deficiency, therapeutic use* Humans Lipid Mobilization / drug effects Methylmalonic Acid / urine* Methylmalonyl-CoA Mutase / deficiency Recombinant Proteins / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Recombinant Proteins; 516-05-2/Methylmalonic Acid; 9002-72-6/Growth Hormone; EC 5.4.99.2/Methylmalonyl-CoA Mutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: No reduction in birth weight in phenylketonuria.
Next Document: Cardiopulmonary function in premature infants with bronchopulmonary dysplasia--a 2-year follow up.