Document Detail


Use of human recombinant erythropoietin for the treatment of nonregenerative anemia in a rough-toothed dolphin (Steno bredanensis).
MedLine Citation:
PMID:  10982125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythropoietin, a glycoprotein growth hormone that is produced primarily in the kidneys, promotes mitosis and survival of erythroid progenitors. The recent synthesis of the human form of the hormone by recombinant technology has provided a new therapeutic option, which is being used in both human and veterinary medicine for treatment of various anemias. A mature male rough-toothed dolphin, Steno bredanensis, was treated with human recombinant erythropoietin in an attempt to resolve a nonregenerative anemia. Two i.m. injections 48 hr apart were associated with an almost immediate increase in circulating immature reticulocytes, total reticulocytes, and nucleated erythrocytes. Over the next several weeks, the hematocrit, hemoglobin, and erythrocyte counts returned to normal, and the animal was subsequently released back into the wild. Endogenous erythropoietin concentrations were determined for this animal as well as three other conspecifics by an enzyme-linked immunosorbent assay for human erythropoietin. These measurements showed circulating erythropoietin concentrations (5-20+ mU/ml) similar to those of most other mammals. This study suggests that human recombinant erythropoietin can be safely and effectively used in this species and may have applicability to other cetacean species for the treatment of nonregenerative anemia. Caution should be exercised during long-term use because production of antibodies to human recombinant and endogenous erythropoietin may lead to potentially serious side effects.
Authors:
C A Manire; H L Rhinehart
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians     Volume:  31     ISSN:  1042-7260     ISO Abbreviation:  J. Zoo Wildl. Med.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2001-02-05     Completed Date:  2001-02-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8915208     Medline TA:  J Zoo Wildl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  IM    
Affiliation:
Dolphin and Whale Hospital, Mote Marine Laboratory, Center for Marine Mammal and Sea Turtle Research, Sarasota, Florida 34236, USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia / drug therapy,  veterinary*
Animals
Anti-Bacterial Agents / therapeutic use
Anti-Ulcer Agents / therapeutic use
Dolphins*
Enzyme-Linked Immunosorbent Assay / veterinary
Erythropoietin, Recombinant / blood,  therapeutic use*
Flow Cytometry / veterinary
Gentamicins / therapeutic use
Glomerulonephritis / drug therapy,  veterinary
Hematocrit / veterinary
Hematuria / veterinary
Hemoglobins / analysis
Male
Proteinuria / veterinary
Ranitidine / therapeutic use
Reference Values
Sucralfate / therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Erythropoietin, Recombinant; 0/Gentamicins; 0/Hemoglobins; 54182-58-0/Sucralfate; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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