Document Detail


Use of human factor VIIa in the treatment of two hemophilia A patients with high-titer inhibitors.
MedLine Citation:
PMID:  6408124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two patients with hemophilia A complicated with high-titer alloantibodies have been treated by repeated infusions of microgram quantities of pure human Factor VIIa. Patient 1 was presented with a gastrocnemius muscle bleeding that involved the knee joint. Upon treatment with Factor VIIa the circumference of the muscle decreased and joint mobility increased substantially. Patient 2 was given Factor VIIa concurrent with tranexamic acid in association with the extraction of two primary molars. No significant gingival bleeding occurred after Factor VIIa and tranexamic acid treatment. Furthermore, no deleterious side effects or increase of the alloantibody level were observed in either patient throughout the Factor VIIa infusion. These results, although limited and preliminary in nature, suggest that trace quantities of Factor VIIa can act as a Factor VIII bypassing activity and restore hemostasis in these patients.
Authors:
U Hedner; W Kisiel
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  71     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1836-41     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antigens / immunology*
Child
Factor VII / therapeutic use*
Factor VIII / immunology*
Factor VIIa
Hemophilia A / drug therapy*,  immunology
Humans
Isoantibodies / analysis*
Male
Tooth Extraction
Tranexamic Acid / therapeutic use
Grant Support
ID/Acronym/Agency:
HL 16919/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Isoantibodies; 1197-18-8/Tranexamic Acid; 9001-25-6/Factor VII; 9001-27-8/Factor VIII; EC 3.4.21.21/Factor VIIa
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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