Document Detail

Use of high-resolution ultrasound to monitor the healing of leg ulcers: a prospective single-center study.
MedLine Citation:
PMID:  19622125     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The quality and extent of leg ulcer healing in deeper skin layers remains poorly defined using standard visual inspection alone. High-resolution ultrasound (HR-US) offers a non-invasive, quantitative and objective assessment of dimensional and structural changes deep within the wound. METHODS: In a prospective, single-center study, healing of chronic, treatment-resistant leg ulcers was monitored by standard photography and HR-US. RESULTS: Twenty patients with 22 ulcers were enrolled. After study entry, treatment comprised continuation of conventional management (n=4) or application of Apligraf (n=17) or Thiersch (n=1). All ulcers receiving a graft were classified as 'clinically healed' by visual inspection within a maximum of 5 weeks. With conventional management, closure required a period of several months in three out of four cases. After covering the ulcer with Apligraf, the skin reconditioned, resulting in fair skin color and a smooth skin surface in all but one case. HR-US images, however, revealed large subepidermal deficits of elastic and collagenous fibers at the time of 'clinical healing' in 14/18 engrafted ulcers, findings that are strongly indicative of a weakened skin scaffolding. CONCLUSION: We suggest that the healing process for chronic ulcers can be monitored with both standard visual inspection (photography) and HR-US to allow early intervention.
Christoph Kuhn; Fiorenzo Angehrn
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)     Volume:  15     ISSN:  1600-0846     ISO Abbreviation:  Skin Res Technol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-07-22     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504453     Medline TA:  Skin Res Technol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  161-7     Citation Subset:  IM    
Clinic Piano, Gottstattstrasse, Biel, Switzerland.
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MeSH Terms
Dermoscopy / methods*
Image Enhancement / methods*
Leg Ulcer / pathology*,  therapy*
Prospective Studies
Treatment Outcome
Ultrasonography / methods*
Wound Healing*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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