Document Detail

Use of high-performance thin layer chromatography by the American Herbal Pharmacopoeia.
MedLine Citation:
PMID:  21140643     Owner:  NLM     Status:  MEDLINE    
TLC characterizations are among the key identity tests in most pharmacopoeial monographs. Pharmacopoeial standards are typically used by industry as a basis for meeting QC requirements and current good manufacturing practices (cGMPs). TLC is a relatively low-cost, highly versatile tool for developing specifications for raw materials, as well as for the various preparations for which pharmacopoeial standards are created. In addition to its use in the development of identity tests, TLC is a valuable tool for screening plant samples that pharmacopoeias must review in the development of monographs and botanical reference materials (BRMs). Specifically, HPTLC is the ideal TLC technique for these purposes because of its increased accuracy, reproducibility, and ability to document the results, compared with standard TLC. Because of this, HPTLC technologies are also the most appropriate TLC technique for conformity with GMPs. This article highlights the manner in which HPTLC is used by the American Herbal Pharmacopoeia (AHP) in the development of AHP monograph identity standards, the identification of adulterating species, and the development of AHP-verified BRMs.
Roy T Upton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of AOAC International     Volume:  93     ISSN:  1060-3271     ISO Abbreviation:  J AOAC Int     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-12-09     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215446     Medline TA:  J AOAC Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1349-54     Citation Subset:  IM    
American Herbal Pharmacopoeia, P.O. Box 66809, Scotts Valley, CA 95067, USA.
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MeSH Terms
Chromatography, Thin Layer / methods*
Drug Contamination
Pharmacopoeias as Topic*
Plant Preparations / analysis*
Plants, Medicinal / chemistry*
Quality Control
Reference Standards
Reg. No./Substance:
0/Plant Preparations

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