Document Detail

Use of herbal drugs during early pregnancy in relation to maternal characteristics and pregnancy outcome.
MedLine Citation:
PMID:  17992658     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study characteristics of women using herbal drugs and the possible impact of use in early pregnancy on pregnancy outcome. METHODS: Data on the use of herbal drugs during pregnancy were obtained from the Swedish Medical Birth Register during the period 1st July 1995 to end of 2004. Women who reported use of herbal drugs were compared to all women giving birth during the period. Outcome variables were prematurity, birth weight, Apgar score, number of infants in delivery and congenital malformations. RESULTS: Among the 860 215 women in the register, 787 (0.9%) reported use of herbal drugs during early pregnancy. The most frequently used herbal drugs were Floradix (iron-rich herbs), ginseng and valerian. Use of such drugs was independently associated with high maternal age, normal weight and 14-15 years of education. Risk factors for valerian differed from those for other herbal drugs, for example with respect to maternal smoking and country of birth. Concomitant drug use was common and the most frequently used drugs were multivitamins, folic acid, cardiovascular drugs (mainly antihypertensive drugs), non-steroid anti-inflammatory drugs (NSAIDs), analgesics and psycholeptics. None of the infant characteristics studied were influenced significantly by the mother's use of the examined herbal drugs during early pregnancy. CONCLUSIONS: The most commonly reported herbal drugs used during pregnancy were Floradix (iron-rich herbs), ginseng and valerian. No signs of unfavourable effect on pregnancy outcome were seen. The number of exposures, however, was low and therefore effects on rare outcomes (e.g. specific malformations) cannot be excluded.
Lone Holst; Hedvig Nordeng; Svein Haavik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacoepidemiology and drug safety     Volume:  17     ISSN:  1099-1557     ISO Abbreviation:  Pharmacoepidemiol Drug Saf     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-07     Completed Date:  2008-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208369     Medline TA:  Pharmacoepidemiol Drug Saf     Country:  England    
Other Details:
Languages:  eng     Pagination:  151-9     Citation Subset:  IM    
Copyright Information:
Copyright 2007 John Wiley & Sons, Ltd.
Department of Chemistry, Centre for Pharmacy, University of Bergen, Bergen, Norway.
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MeSH Terms
Apgar Score
Birth Weight / drug effects
Congenital Abnormalities / etiology
Educational Status
Iron Compounds / adverse effects
Maternal Age
Panax / adverse effects
Phytotherapy / adverse effects*
Plant Preparations / adverse effects*
Plants, Medicinal / adverse effects*
Pregnancy Complications / drug therapy
Pregnancy Outcome*
Pregnancy, Multiple
Premature Birth / etiology
Registries / statistics & numerical data
Risk Factors
Valerian / adverse effects
Reg. No./Substance:
0/Iron Compounds; 0/Plant Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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