Document Detail


Use of a hemoglobin-based oxygen carrier in the treatment of severe anemia.
MedLine Citation:
PMID:  15121621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hemoglobin-based oxygen carriers hold promise for the treatment of acute anemia. CASE: We report a patient with severe dysfunctional uterine bleeding. During her hospitalization, her lowest hemoglobin level was 3.1 g/dL, with a hematocrit of 9.3%. An investigational product, o-raffinose cross-linked human hemoglobin solution (hemoglobin raffimer), was infused along with ongoing high-dose recombinant human erythropoietin and estrogen. The time until the patient's own hematopoiesis provided sufficient red blood cell mass was successfully managed by reducing oxygen demand and providing multiple hemoglobin-based oxygen carrier infusions. After hemoglobin-based oxygen carrier administration, transient pulmonary hypertension and fever were noted. She was discharged after corrective surgery 7 days after hemoglobin-based oxygen carrier administration with a hemoglobin level of 7.8 g/dL. CONCLUSION: The hemoglobin level-based oxygen carrier improved oxygen delivery and permitted uterine corrective surgery.
Authors:
Aryeh Shander; Raed Alalawi; Petra Seeber; John Lui
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  103     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-06-04     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1096-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology and Critical Care Medicine, Englewood Hospital and Medical Center, Englewood, New Jersey 07631, USA. aryeh.shander@ehmc.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / etiology,  therapy*
Emergencies
Female
Hematocrit
Hemoglobins / analysis,  therapeutic use*
Humans
Hypertension, Pulmonary / etiology
Jehovah's Witnesses
Menorrhagia / complications*
Raffinose / analogs & derivatives*,  therapeutic use*
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/O-raffinose cross-linked human hemoglobin; 512-69-6/Raffinose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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