| Use of a hemoglobin-based oxygen carrier in the treatment of severe anemia. | |
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MedLine Citation:
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PMID: 15121621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hemoglobin-based oxygen carriers hold promise for the treatment of acute anemia. CASE: We report a patient with severe dysfunctional uterine bleeding. During her hospitalization, her lowest hemoglobin level was 3.1 g/dL, with a hematocrit of 9.3%. An investigational product, o-raffinose cross-linked human hemoglobin solution (hemoglobin raffimer), was infused along with ongoing high-dose recombinant human erythropoietin and estrogen. The time until the patient's own hematopoiesis provided sufficient red blood cell mass was successfully managed by reducing oxygen demand and providing multiple hemoglobin-based oxygen carrier infusions. After hemoglobin-based oxygen carrier administration, transient pulmonary hypertension and fever were noted. She was discharged after corrective surgery 7 days after hemoglobin-based oxygen carrier administration with a hemoglobin level of 7.8 g/dL. CONCLUSION: The hemoglobin level-based oxygen carrier improved oxygen delivery and permitted uterine corrective surgery. |
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Authors:
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Aryeh Shander; Raed Alalawi; Petra Seeber; John Lui |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 103 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-03 Completed Date: 2004-06-04 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1096-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Critical Care Medicine, Englewood Hospital and Medical Center, Englewood, New Jersey 07631, USA. aryeh.shander@ehmc.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / etiology, therapy* Emergencies Female Hematocrit Hemoglobins / analysis, therapeutic use* Humans Hypertension, Pulmonary / etiology Jehovah's Witnesses Menorrhagia / complications* Raffinose / analogs & derivatives*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/O-raffinose cross-linked human hemoglobin; 512-69-6/Raffinose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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