| Use of hemodialysis after ingestion of a mixture of acids containing hydrofluoric acid. | |
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MedLine Citation:
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PMID: 22011695 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hydrofluoric acid (HF) is a highly toxic poison that can be rapidly fatal. Death usually results from the many systemic effects of dissociated fluoride ions, including hypocalcemia, hypomagnesemia, hyperkalemia, and direct cardiotoxicity. A patient is described who accidentally ingested a hydrofluoric acid-containing substance and who likely benefited from hemodialysis. His fluoride level post-dialysis was reduced by approximately 70% from a level drawn three hours prior to the initiation of hemodialysis. However, the single treatment did not reduce the fluoride level to normal. A review of the pathophysiology of hydrofluoric acid intoxication and the outcomes of prior exposures suggests that hemodialysis could play a vital role in the management of poisonings with fluoride-containing substances. However, the initial hemodialysis treatment should be prolonged beyond the standard four-hour session. |
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Authors:
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M Antar-Shultz; S I Rifkin; C McFarren |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology and therapeutics Volume: 49 ISSN: 0946-1965 ISO Abbreviation: Int J Clin Pharmacol Ther Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423309 Medline TA: Int J Clin Pharmacol Ther Country: Germany |
Other Details:
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Languages: eng Pagination: 695-9 Citation Subset: IM |
Affiliation:
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University of South Florida, Division of Nephrology and Hypertension, Tampa, FL, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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