Document Detail

Use of heart rate spectral analysis to study the effects of calcium channel blockers on sympathetic activity after myocardial infarction.
MedLine Citation:
PMID:  2296878     Owner:  NLM     Status:  MEDLINE    
We used spectral analysis of heart rate variability (HRV) to study the effects of the calcium channel blockers diltiazem and nifedipine and the beta-blocker metoprolol on the sympathetic nervous system in patients following myocardial infarction. Energy in the low-frequency range (0.04 to 0.12 Hz) in the standing (tilt) position was used as a quantitative index of sympathetic activity. Twenty-seven male patients, mean age 62 +/- 13 years, were studied 2 to 6 weeks after myocardial infarction. Eight patients received metoprolol, 100 mg twice daily; nine patients received diltiazem, 60 mg three times daily; and 10 patients received nifedipine, 10 mg three times daily. HRV and arterial blood pressure were recorded before and 5 to 7 days after initiation of therapy. None of the drugs had significant effects on the systolic blood pressure, and only nifedipine significantly reduced the diastolic blood pressure. Metoprolol and diltiazem reduced the low-frequency HRV in all patients studied, but nifedipine had no consistent effects. Our results suggest that diltiazem had a depressant effect on sympathetic activity similar to beta-adrenergic blockers. This effect was not observed with nifedipine. The reduction in sympathetic activity by diltiazem may contribute to its therapeutic effects in the post-infarction period.
S Bekheit; M Tangella; A el-Sakr; Q Rasheed; W Craelius; N el-Sherif
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  119     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-14     Completed Date:  1990-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  AIM; IM    
Department of Medicine, State University of New York Health Science Center, Brooklyn.
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MeSH Terms
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use*
Diltiazem / therapeutic use
Heart Rate*
Metoprolol / therapeutic use
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology
Nifedipine / therapeutic use
Sympathetic Nervous System / drug effects,  physiopathology*
Grant Support
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 37350-58-6/Metoprolol; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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