Document Detail

Use of growth hormone for postoperative respiratory failure.
MedLine Citation:
PMID:  8678203     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The authors examined the efficacy of human growth hormone (HGH) in patients dependent on mechanical ventilation who were being weaned from the respirator. METHODS: A total of 53 patients were chosen by the primary surgical team in consultation with the critical care service to undergo HGH therapy. These patients had been receiving standard ICU support and had failed standard ventilator weaning protocols. As such, they were treated with HGH in an attempt to increase respiratory muscle strength and facilitate weaning from mechanical ventilation. RESULTS: General demographic information was recorded. Patients suffered from a high incidence of co-morbid conditions and infectious complications. The average duration of HGH therapy was 38 days, and 81% of the previously unweanable patients were eventually weaned from mechanical ventilation with an overall survival of 76%. Mortality as predicted by APACHE II Scores was significantly less than actual mortality (24% actual mortality vs. 42% predicted mortality, P < 0.05). CONCLUSIONS: This phase I study presents clinical evidence supporting the safety and efficacy of HGH in promoting respiratory independence in a selected group of surgical ICU patients. Randomized, blinded, controlled trials now seem warranted.
J B Knox; D W Wilmore; R H Demling; P Sarraf; A A Santos
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase I; Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  171     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-15     Completed Date:  1996-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  576-80     Citation Subset:  AIM; IM    
Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
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MeSH Terms
Critical Illness
Growth Hormone / therapeutic use*
Middle Aged
Postoperative Complications / drug therapy*
Respiration, Artificial
Respiratory Insufficiency / drug therapy*,  etiology*
Retrospective Studies
Treatment Outcome
Ventilator Weaning
Reg. No./Substance:
9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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