Document Detail

Use of a gonadotropin-releasing hormone agonist in the evaluation of postmenopausal virilization due to ovarian hyperthecosis. A case report.
MedLine Citation:
PMID:  8728079     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyperthecosis in a postmenopausal woman is a very rare cause of virilization, and only five cases have been reported previously. CASE: A woman presented with a nine-year history of increasing hirsutism and a mild virilization beginning in the perimenopausal period. Initial androgen metabolite concentrations suggested attenuated late-onset adrenal hyperplasia, but a trial of dexamethasone treatment was ineffective. Subsequent use of leuprolide acetate resulted in a biochemical and clinical improvement in the signs and symptoms. CONCLUSION: This case is unique because gonadotropin-releasing hormone agonist administration was utilized as both a diagnostic and therapeutic modality.
T M Koroscil; S B Harter; J Ouweleen; K L Blauer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  41     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-10     Completed Date:  1996-10-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Wright-Patterson United States Air Force Medical Center, Ohio 45433-5529, USA.
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MeSH Terms
Adrenocortical Hyperfunction / blood,  etiology,  physiopathology
Androgens / blood
Delayed-Action Preparations
Drug Therapy, Combination
Estrogens, Conjugated (USP) / therapeutic use
Fallopian Tubes / surgery
Gonadotropin-Releasing Hormone / agonists*
Gonadotropins / blood
Hyperplasia / pathology
Leuprolide / administration & dosage,  diagnostic use*,  therapeutic use
Medroxyprogesterone Acetate / therapeutic use
Middle Aged
Ovarian Diseases / complications*,  pathology,  physiopathology,  therapy
Ovary / pathology
Progesterone Congeners / therapeutic use
Virilism / diagnosis,  etiology*,  physiopathology
Reg. No./Substance:
0/Androgens; 0/Delayed-Action Preparations; 0/Estrogens, Conjugated (USP); 0/Gonadotropins; 0/Progesterone Congeners; 33515-09-2/Gonadotropin-Releasing Hormone; 53714-56-0/Leuprolide; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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