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Use of the glycophorin A human mutation assay to study workers exposed to styrene.
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MedLine Citation:
PMID:  8319648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The glycophorin A (GPA) assay is a human mutation assay that is potentially useful for large epidemiological studies. The assay is rapid and requires a minimal amount of blood, which can be stored before analysis. The data presented here were collected from workers exposed to styrene in a boat manufacturing plant. This study was the first to apply the GPA assay to an occupationally exposed population. Subjects with a mean styrene exposure of 30 ppm had a higher frequency of GPA N phi variant cells than subjects with mean exposure of 1 ppm, but the subjects differed in respect to smoking and age distribution. Results indicate that the original 1-W-1 version of the assay may not be suitable for studies of small numbers of exposed subjects due to variability and artifacts. The newer BR6 version, however, has much lower variability and shows promise for use in the occupational setting.
Authors:
P J Compton-Quintana; R H Jensen; W L Bigbee; S G Grant; R G Langlois; M T Smith; S M Rappaport
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  99     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-301     Citation Subset:  IM    
Affiliation:
Department of Environmental Health Sciences, University of California, Berkeley 94720.
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MeSH Terms
Descriptor/Qualifier:
Evaluation Studies as Topic
Gene Frequency
Genetic Variation
Glycophorin / genetics*
Humans
Mutagenicity Tests / methods*
Occupational Exposure*
Styrene
Styrenes / adverse effects*
Grant Support
ID/Acronym/Agency:
CA48518/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Glycophorin; 0/Styrenes; 100-42-5/Styrene
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 3 Year: 1993
Volume: 99First Page: 297 Last Page: 301
ID: 1567018
PubMed Id: 8319648

Use of the glycophorin A human mutation assay to study workers exposed to styrene.
P J Compton-Quintana
R H Jensen
W L Bigbee
S G Grant
R G Langlois
M T Smith
S M Rappaport
Department of Environmental Health Sciences, University of California, Berkeley 94720.



Article Categories:
  • Research Article


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