Document Detail

Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis.
MedLine Citation:
PMID:  12065336     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The anaerobic threshold (AT) is a submaximal index related to endurance exercise performance, which is usually determined by the measurement of blood lactate concentration during an incremental exercise test (lactate threshold [LT]). The LT, and thus the AT, can also be detected noninvasively in normal subjects by means of the gas exchange threshold (GET). This study was undertaken to validate the use of GET in patients with cystic fibrosis (CF) with a wide range of disease severity, and to assess the reproducibility of this index. METHODS: In patients with CF (FEV(1) range, 23 to 118% of predicted) and control subjects, gas exchange was measured breath by breath during the incremental exercise tests to allow determination of the GET. Arterialized-venous blood was sampled for determination of the LT. The GET and LT were determined in a blinded manner. RESULTS: The mean differences (GET - LT) for control subjects (n = 18) and patients with CF (n = 23) were - 40 mL/min and + 10 mL/min, respectively, neither being significantly different from zero. The limits of agreement were +/- 550 mL/min and +/- 410 mL/min, respectively. The mean test-retest differences in GET for control subjects (n = 14) and patients with CF (n = 12) were - 50 mL/min and 0 mL/min, respectively, neither being significantly different from zero; the respective limits of reproducibility were +/- 450 mL/min and +/- 350 mL/min. CONCLUSIONS: This study demonstrates that in patients with CF, the GET can be used to obtain an unbiased estimate of the LT, and that the GET is reproducible.
Alasdair G Thin; Seamus J Linnane; Edward F McKone; Rosemarie Freaney; Muiris X FitzGerald; Charles G Gallagher; Paul McLoughlin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chest     Volume:  121     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-14     Completed Date:  2002-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1761-70     Citation Subset:  AIM; IM    
Department of Physiology, Conway Institute of Biomedical and Biomolecular Research, University College, Dublin, Ireland.
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MeSH Terms
Cystic Fibrosis / metabolism*
Lactic Acid / metabolism*
Pulmonary Gas Exchange*
Reproducibility of Results
Reg. No./Substance:
50-21-5/Lactic Acid

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