Document Detail


Use of food wafers for multiple daily oral treatments in young rats.
MedLine Citation:
PMID:  19476719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many laboratory studies require oral administration of drugs. Dietary administration in food or water is useful, but is not always the best method. Orogastric gavage can be stressful. Here, we describe in detail a relatively stress-free technique that can be applied to multiple daily administrations using a palatable food item. This method was successfully used to administer water or methylphenidate 3 times daily to young pair-housed adolescent rats.
Authors:
Sherry A Ferguson; Sherin Y Boctor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Association for Laboratory Animal Science : JAALAS     Volume:  48     ISSN:  1559-6109     ISO Abbreviation:  J. Am. Assoc. Lab. Anim. Sci.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-07-16     Revised Date:  2013-03-13    
Medline Journal Info:
Nlm Unique ID:  101269489     Medline TA:  J Am Assoc Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
Affiliation:
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA. Sherry.Ferguson@fda.hhs.gov
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animal Feed*
Animals
Drug Delivery Systems / methods*
Methylphenidate / administration & dosage
Rats
Chemical
Reg. No./Substance:
113-45-1/Methylphenidate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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