Document Detail


Use of the fluorochromes xylenol orange, calcein green, and tetracycline to document bone deposition and remodeling in healing fractures in chickens.
MedLine Citation:
PMID:  1627115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fluorescent calcium binding dyes xylenol orange, calcein green, and tetracycline were used successfully to sequentially label new bone deposition and bone remodeling during the healing of rigidly fixed humeral fractures in the chicken. Xylenol orange and calcein green, administered subcutaneously at 90 mg/kg and 10 mg/kg, respectively, provided easily identified and differentiated bands in newly deposited bone within periosteal and endosteal calluses, intercortical gaps, and screw holes. Tetracycline, administered at 50 mg/kg per os by crop tube, labeled bone faintly in a non-specific manner. Parenteral administration of the same compound might have yielded better results.
Authors:
A J Stuart; D A Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Avian diseases     Volume:  36     ISSN:  0005-2086     ISO Abbreviation:  Avian Dis.     Publication Date:    1992 Apr-Jun
Date Detail:
Created Date:  1992-08-13     Completed Date:  1992-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370617     Medline TA:  Avian Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-9     Citation Subset:  IM    
Affiliation:
Department of Pathology, Ontario Veterinary College, University of Guelph, Canada.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Bone Remodeling*
Chickens / injuries*
Female
Fluoresceins / administration & dosage,  diagnostic use
Fluorescent Dyes / administration & dosage,  diagnostic use*
Humeral Fractures / physiopathology,  veterinary*
Indicators and Reagents
Injections, Subcutaneous / veterinary
Tetracycline / administration & dosage,  diagnostic use
Wound Healing
Xylenes / administration & dosage,  diagnostic use
Chemical
Reg. No./Substance:
0/Fluoresceins; 0/Fluorescent Dyes; 0/Indicators and Reagents; 0/Xylenes; 1461-15-0/fluorexon; 1611-35-4/xylenol orange; 60-54-8/Tetracycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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