| Use of fibrin sealant in thermal injury. | |
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MedLine Citation:
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PMID: 9313125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrin glue is hemostatic in skin grafting and other therapeutic situations. This prospective, open-labeled comparative study involved thermally injured patients: 34 patients received fibrin sealant (FS) and 61 did not, at Loyola University Medical Center, Maywood, Illinois, and Shriners Burn Institute, Cincinnati, Ohio. FS-treated patients were 23.6 +/- 16.8 years old, versus 20.8 +/- 16.8 years for controls. The percentage of total body surface areas burn was 10.0% +/- 4.5% in the study patients versus 10.9% +/- 7.9% in the controls. The FS group did not receive packed red blood cell transfusions, albumin infusion, or topical bovine thrombin (TBT). The control group received 1.56 +/- 2.1 units of packed red blood cells, 186 +/- 194 ml 5% albumin, and TBT (20,000 units) 2.6 +/- 0.8 kits during excision and grafting procedures. The estimated blood loss/graft ration was 0.50 +/- 0.30 ml/cm2 (median = 0.46) for the study group versus 0.98 +/- 2.4 ml/cm2 (median = 0.56) for the control group (p = 0.14); for patients more than 16 years of age, this difference was significant (p = 0.03). FS may be a viable alternative to standard hemostatic techniques, because it reduced the need for blood transfusion, alloantigen exposure, and blood-borne viral infection risk. FS also eliminated the need for TBT and epinephrine, did not have an adverse impact on the surgical outcome, and tended to improve the cost differential. |
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Authors:
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V McGill; A Kowal-Vern; M Lee; D Greenhalgh; E Gomperts; G Bray; R Gamelli |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 18 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1997 Sep-Oct |
Date Detail:
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Created Date: 1997-10-30 Completed Date: 1997-10-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 429-34 Citation Subset: IM |
Affiliation:
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Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Loss, Surgical Blood Transfusion Blood-Borne Pathogens Burns / complications, therapy* Child Child, Preschool Female Fibrin Tissue Adhesive / therapeutic use* Hemostatic Techniques* Hospital Costs Humans Infection Control Length of Stay Male Skin Transplantation* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Tissue Adhesive |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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