Document Detail

Use of fetal analgesia during prenatal surgery.
MedLine Citation:
PMID:  22881840     Owner:  NLM     Status:  Publisher    
Abstract Recent progresses in fetal surgery have raised concern on fetal pain, its long-term consequences and the risks of sudden fetal movements induced by pain. In several studies, surgeons have directly administered opioids to the fetus, while others have considered sufficient the maternally administered analgesics. We performed a review of the literature to assess the state of the art. Methods: We performed a PubMed search to retrieve the papers that in the last 10 years reported studies of human fetal surgery and that described whether any fetal analgesia was administered. Results: We retrieved 34 papers. In 3 papers, the procedure did not hurt the fetus, being performed on fetal annexes, in 2 papers it was performed in the first trimester of pregnancy, when pain perception is unlikely. Ten of the 29 remaining papers were performed using direct fetal analgesia, while in 19, analgesia was administered only to the mother. In most cases, fetal direct analgesia was obtained using i.m. opioids, and muscle relaxant. No drawbacks on either fetuses or mothers were reported, due to fetal analgesia. Conclusion: Fetal direct analgesia is performed only in a minority of cases. More research is needed to assess or exclude its possible long-term drawbacks, as well as the actual consequences of pain during surgery.
C V Bellieni; M Tei; G Stazzoni; S Bertrando; G Buonocore
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, Obstetrics and Reproduction Medicine, University of Siena, Italy.
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