| Use of erythromycin to prevent pertussis in newborns of mothers with pertussis. | |
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MedLine Citation:
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PMID: 2883239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the period 1975-1985, 35 women with serology- or culture-confirmed pertussis at the time of labor were admitted to the Danderyd Hospital (Danderyd, Sweden). In 32 cases, the mothers were allowed to nurse their newborns while receiving erythromycin therapy. Erythromycin prophylaxis was given to 28 newborns. None of the newborns developed clinical or laboratory signs of whooping cough. The therapy was well tolerated by the newborns and did not affect the microflora in the gut. Maternal antibodies to pertussis toxin and to the filamentous hemagglutinin were found in cord blood, and levels decreased during the follow-up period. The study demonstrated that mothers with pertussis can safely be allowed to nurse their infants if both receive erythromycin. |
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Authors:
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G Granström; G Sterner; C E Nord; M Granström |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 155 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-06-19 Completed Date: 1987-06-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1210-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Bacterial
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analysis Antitoxins / analysis Bordetella pertussis / immunology Erythromycin / therapeutic use* Female Fetal Blood / immunology Hemagglutinins / immunology Humans Infant, Newborn Labor, Obstetric Pertussis Toxin Pregnancy Pregnancy Complications, Infectious / epidemiology Virulence Factors, Bordetella / immunology Whooping Cough / drug therapy, epidemiology, prevention & control*, transmission |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Antitoxins; 0/Hemagglutinins; 0/Virulence Factors, Bordetella; 114-07-8/Erythromycin; EC 2.4.2.31/Pertussis Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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