Document Detail

Use of erlotinib throughout pregnancy: a case-report of a patient with metastatic lung adenocarcinoma.
MedLine Citation:
PMID:  22534670     Owner:  NLM     Status:  MEDLINE    
The use of erlotinib throughout pregnancy has not been previously reported. We present the case of a 40 year-old female patient with stage IV lung adenocarcinoma, mediastinal, bone and cerebral metastasis, a EGFR mutation and no smoking history, who had begun first line treatment with erlotinib 150 mg once daily. After two and a half months of treatment a fourteen-week pregnancy was documented, and after informing on fetal risks secondary to erlotinib use and maternal risks secondary to treatment withholding, she decided to continue with treatment under clinical surveillance by both the oncology and obstetrics clinics. At thirty-three weeks gestation a live born 1600 g female was born by caesarean section without evidence of congenital malformations. Imaging assessment after eight months of treatment showed complete bone and central nervous system response and partial lung and mediastinal response. The patient is currently undergoing the 11th month of treatment and is asymptomatic, the baby is 4 months old and is in good health.
Giovanna Rivas; Nestor Llinás; Carlos Bonilla; Juan Rubiano; Javier Cuello; Natalia Arango
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-04-24
Journal Detail:
Title:  Lung cancer (Amsterdam, Netherlands)     Volume:  77     ISSN:  1872-8332     ISO Abbreviation:  Lung Cancer     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-11-07     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8800805     Medline TA:  Lung Cancer     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  469-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Clinical Oncology Group, Cancerology National Institute, E.S.E., Bogota, Colombia.
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MeSH Terms
Adenocarcinoma / diagnosis,  drug therapy*,  genetics
Antineoplastic Agents / therapeutic use*
Base Sequence
Lung Neoplasms / diagnosis,  drug therapy*,  genetics
Neoplasm Metastasis
Pregnancy Complications, Neoplastic / diagnosis,  drug therapy*
Pregnancy Outcome
Protein Kinase Inhibitors / therapeutic use*
Quinazolines / therapeutic use*
Receptor, Epidermal Growth Factor / antagonists & inhibitors,  genetics
Treatment Outcome
Reg. No./Substance:
0/Antineoplastic Agents; 0/Protein Kinase Inhibitors; 0/Quinazolines; EC, Epidermal Growth Factor; J4T82NDH7E/erlotinib

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