Document Detail


Use of enzyme replacement therapy for Gaucher disease during pregnancy.
MedLine Citation:
PMID:  9423759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To date there has been little published experience with enzyme replacement therapy in pregnant women with symptomatic type I Gaucher disease. STUDY DESIGN: We describe six patients, including three with repeated early pregnancy loss, five of whom successfully carried pregnancies to term; the last pregnancy was terminated because of pulmonary hypertension. RESULTS: All pregnancies were uneventful and five resulted in healthy newborns. CONCLUSION: We concluded that in patients with Gaucher disease of childbearing age,for whom obstetric complications are an important symptom of the disease, pregnancy is not contraindicated (unless there is evidence or suspicion of pulmonary hypertension) and treatment should not be interrupted because the clinical improvement engendered by enzyme replacement therapy is conducive to fewer complications during pregnancy and delivery and post partum.
Authors:
D Elstein; S Granovsky-Grisaru; R Rabinowitz; R Kanai; A Abrahamov; A Zimran
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  177     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-01-26     Completed Date:  1998-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1509-12     Citation Subset:  AIM; IM    
Affiliation:
Gaucher Clinic, Shaare-Zedek Medical Center, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / complications
Adult
Female
Gaucher Disease / complications,  drug therapy*
Glucosylceramidase / therapeutic use*
Humans
Pregnancy
Pregnancy Complications / drug therapy*
Pregnancy Outcome
Treatment Outcome
Chemical
Reg. No./Substance:
EC 3.2.1.-/alglucerase; EC 3.2.1.45/Glucosylceramidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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