Document Detail

Use of enriched stable isotopes to determine bioavailability of trace elements in humans.
MedLine Citation:
PMID:  6879158     Owner:  NLM     Status:  MEDLINE    
Use of stable isotopes with analysis by thermal ionization mass spectrometry can determine trace element availability from dietary sources safely and with a high degree of accuracy. Stable isotopes of zinc (70Zn), copper (65Cu) and iron (58Fe) were fed with semipurified diets to humans. Excretion of isotopes was determined by isotope dilution in fecal composites collected for 15 days following the feedings. A thermal ionization, magnetic sector mass spectrometer was used to measure isotopic ratios. Total mineral content of fecal composites was determined by atomic absorption spectrophotometry. Mean absorption of zinc, iron and copper in six elderly men was 17.3, 8.7 and 26.0% respectively. Results agreed closely with absorption determined simultaneously in the same subjects using radioisotopes.
J R Turnlund
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Science of the total environment     Volume:  28     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  IM    
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MeSH Terms
Biological Availability
Copper / metabolism
Feces / analysis
Iron / metabolism
Iron Isotopes
Spectrophotometry, Atomic / methods
Trace Elements / metabolism*
Zinc / metabolism
Zinc Isotopes
Grant Support
Reg. No./Substance:
0/Iron Isotopes; 0/Isotopes; 0/Trace Elements; 0/Zinc Isotopes; 7439-89-6/Iron; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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