Document Detail

Use of dynamic compliance for open lung positive end-expiratory pressure titration in an experimental study.
MedLine Citation:
PMID:  17110872     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We tested whether the continuous monitoring of dynamic compliance could become a useful bedside tool for detecting the beginning of collapse of a fully recruited lung. DESIGN: Prospective laboratory animal investigation. SETTING: Clinical physiology research laboratory, University of Uppsala, Sweden. SUBJECTS: Eight pigs submitted to repeated lung lavages. INTERVENTIONS: Lung recruitment maneuver, the effect of which was confirmed by predefined oxygenation, lung mechanics, and computed tomography scan criteria, was followed by a positive end-expiratory pressure (PEEP) reduction trial in a volume control mode with a tidal volume of 6 mL/kg. Every 10 mins, PEEP was reduced in steps of 2 cm H2O starting from 24 cm H2O. During PEEP reduction, lung collapse was defined by the maximum dynamic compliance value after which a first measurable decrease occurred. Open lung PEEP according to dynamic compliance was then defined as the level of PEEP before the point of collapse. This value was compared with oxygenation (Pao2) and CT scans. MEASUREMENTS AND MAIN RESULTS: Pao2 and dynamic compliance were monitored continuously, whereas computed tomography scans were obtained at the end of each pressure step. Collapse defined by dynamic compliance occurred at a PEEP of 14 cm H2O. This level coincided with the oxygenation-based collapse point when also shunt started to increase and occurred one step before the percentage of nonaerated tissue on the computed tomography exceeded 5%. Open lung PEEP was thus at 16 cm H2O, the level at which oxygenation and computed tomography scan confirmed a fully open, not yet collapsed lung condition. CONCLUSIONS: In this experimental model, the continuous monitoring of dynamic compliance identified the beginning of collapse after lung recruitment. These findings were confirmed by oxygenation and computed tomography scans. This method might become a valuable bedside tool for identifying the level of PEEP that prevents end-expiratory collapse.
Fernando Suarez-Sipmann; Stephan H Böhm; Gerardo Tusman; Tanja Pesch; Oliver Thamm; Hajo Reissmann; Andreas Reske; Anders Magnusson; Göran Hedenstierna
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Critical care medicine     Volume:  35     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-01-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-21     Citation Subset:  AIM; IM    
Intensive Care Unit, Fundación Jiménez Díaz-Capio, Avenida de los Reyes Católicos 2, 28010 Madrid, Spain.
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MeSH Terms
Airway Resistance
Blood Gas Analysis
Blood Pressure
Cardiac Output
Disease Models, Animal*
Lung Compliance*
Monitoring, Physiologic / methods*,  standards
Oxygen Consumption
Point-of-Care Systems
Positive-Pressure Respiration* / adverse effects,  methods
Prospective Studies
Pulmonary Atelectasis / blood,  diagnosis*,  etiology,  physiopathology
Pulmonary Wedge Pressure
Respiratory Distress Syndrome, Adult / therapy
Respiratory Insufficiency / therapy
Respiratory Mechanics
Sensitivity and Specificity
Tidal Volume
Tomography, X-Ray Computed
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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