Document Detail

Use of donepezil for the treatment of mild-moderate Alzheimer's disease: an audit of the assessment and treatment of patients in routine clinical practice.
MedLine Citation:
PMID:  11044869     Owner:  NLM     Status:  MEDLINE    
There have been a number of randomised, placebo-controlled trials of donepezil in the treatment of mild-moderate Alzheimer's disease and these report significant benefits for a proportion of patients. Little is known about the use of donepezil in routine clinical practice. The aims of this study were to examine the use of donepezil in routine clinical practice and to identify some of the practical and resource implications associated with treatment. A number of areas were examined against published guidelines including assessment, diagnosis, initiation of treatment, monitoring and discontinuation of treatment. This was a retrospective case note study involving patients with mild - moderate Alzheimer's disease over a one-year period. One hundred and seventeen patients were commenced on donepezil and 93 successfully completed three months of treatment. Of these, 47% demonstrated an improvement in cognition, activities of daily living or carer observation (or a combination). Compliance with accepted guidelines with respect to assessment, diagnosis and monitoring requires a standardised approach that has both clinical and resource implications.
I Cameron; S Curran; P Newton; D Petty; J Wattis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of geriatric psychiatry     Volume:  15     ISSN:  0885-6230     ISO Abbreviation:  Int J Geriatr Psychiatry     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-22     Completed Date:  2000-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710629     Medline TA:  Int J Geriatr Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  887-91     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Ltd.
Consultant in Public Health Medicine, Leeds Health Authority, Leeds, UK.
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MeSH Terms
Activities of Daily Living / psychology
Aged, 80 and over
Alzheimer Disease / drug therapy*,  psychology
Cognition / drug effects
Drug Utilization / statistics & numerical data
Drug Utilization Review
Family Practice / statistics & numerical data
Great Britain
Guideline Adherence
Indans / therapeutic use*
Medical Records
Middle Aged
Nootropic Agents / therapeutic use*
Physician's Practice Patterns / statistics & numerical data*
Piperidines / therapeutic use*
Psychiatric Status Rating Scales
Retrospective Studies
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Indans; 0/Nootropic Agents; 0/Piperidines; 120011-70-3/donepezil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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