| Use of diuretics in cirrhosis and nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 10598545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Patients with cirrhosis and with nephrotic syndrome have subnormal responses to diuretics. The mechanism of this effect in cirrhosis is decreased pharmacodynamics of response. Large doses of diuretic are not useful in this setting. Instead, more frequent administration of modest doses is required. In nephrotic syndrome, substantial amounts of diuretic are rendered inactive by binding to urinary albumin, thereby mandating larger doses. In addition, the pharmacodynamics of response are altered so that doses must be administered more frequently. Rarely, patients may benefit from combinations of albumin and a loop diuretic. |
| | |
Authors:
|
D C Brater |
Related Documents
:
|
879945 - Erythrocytosis associated with the nephrotic syndrome. 15372515 - Congenital nephrosis, mesangial sclerosis, and distinct eye abnormalities with microcor... 2644575 - A case of nephrotic syndrome with glomerular lipoprotein deposition with capillary ball... 12590285 - Spontaneous resolution of infantile nephrotic syndrome. 10632485 - Misplacement of dysplastic epithelium in peutz-jeghers polyps: the ultimate diagnostic ... 1313385 - Ultrasound study in the diagnosis of primary budd-chiari syndrome (obstruction of the i... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Seminars in nephrology Volume: 19 ISSN: 0270-9295 ISO Abbreviation: Semin. Nephrol. Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 2000-01-11 Completed Date: 2000-01-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 575-80 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5124, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Diuretics
/
administration & dosage*,
adverse effects Dose-Response Relationship, Drug Humans Liver Cirrhosis / drug therapy* Nephrotic Syndrome / drug therapy* Prognosis Risk Assessment Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
AG07631/AG/NIA NIH HHS; DK37994/DK/NIDDK NIH HHS; RR00750/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Diuretics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diuretics: correct use in hypertension.
Next Document: Diuretic resistance: physiology and therapeutics.