| Use of the disappearance rate for the estimation of lymphatic absorption during CAPD. | |
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MedLine Citation:
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PMID: 1284998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies are discussed which investigated the usefulness of the disappearance rate of macromolecules from the peritoneal cavity for estimating convective fluid loss from the peritoneal cavity into the peritoneal lymphatic system. It is shown that dextrans are removed from the peritoneal cavity by a size-independent process at a mean rate of 1.37 +/- 0.15 ml/min, whereas the clearance from blood to dialysate of dextrans is size-dependent. The fluid removal rate estimated by the difference in bidirectional transport of inulin (1.79 +/- 0.38 ml/min; p < 0.0005) was of the same order of magnitude as has been found using the removal rate of macromolecules from the peritoneal cavity. Also, the role of local accumulation of macromolecules was studied during continuous administration of dextrans. No differences were found in the dextran disappearance rate before and after saturation of the peritoneal interstitium with dextran (1.1 +/- 0.6 vs. 1.0 +/- 0.4 ml/min). During a study using a hypoosmotic solution we calculated a net transcapillary backfiltration of fluid, whereas the dextran removal rate was in the same order of magnitude as found using commercially available dialysate. In our opinion, the disappearance rate of macromolecules is an estimate of convective fluid loss from the peritoneal cavity into the peritoneal lymphatic system. |
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Authors:
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D G Struijk; A L Imholz; R T Krediet; G C Koomen; L Arisz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Blood purification Volume: 10 ISSN: 0253-5068 ISO Abbreviation: Blood Purif. Publication Date: 1992 |
Date Detail:
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Created Date: 1993-10-14 Completed Date: 1993-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 182-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Animals Dextrans / pharmacokinetics Extracellular Space / metabolism Humans Lymphatic System / metabolism* Osmolar Concentration Peritoneal Cavity / physiology Peritoneal Dialysis, Continuous Ambulatory* Solutions |
| Chemical | |
Reg. No./Substance:
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0/Solutions; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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