Document Detail

Use of the disappearance rate for the estimation of lymphatic absorption during CAPD.
MedLine Citation:
PMID:  1284998     Owner:  NLM     Status:  MEDLINE    
Several studies are discussed which investigated the usefulness of the disappearance rate of macromolecules from the peritoneal cavity for estimating convective fluid loss from the peritoneal cavity into the peritoneal lymphatic system. It is shown that dextrans are removed from the peritoneal cavity by a size-independent process at a mean rate of 1.37 +/- 0.15 ml/min, whereas the clearance from blood to dialysate of dextrans is size-dependent. The fluid removal rate estimated by the difference in bidirectional transport of inulin (1.79 +/- 0.38 ml/min; p < 0.0005) was of the same order of magnitude as has been found using the removal rate of macromolecules from the peritoneal cavity. Also, the role of local accumulation of macromolecules was studied during continuous administration of dextrans. No differences were found in the dextran disappearance rate before and after saturation of the peritoneal interstitium with dextran (1.1 +/- 0.6 vs. 1.0 +/- 0.4 ml/min). During a study using a hypoosmotic solution we calculated a net transcapillary backfiltration of fluid, whereas the dextran removal rate was in the same order of magnitude as found using commercially available dialysate. In our opinion, the disappearance rate of macromolecules is an estimate of convective fluid loss from the peritoneal cavity into the peritoneal lymphatic system.
D G Struijk; A L Imholz; R T Krediet; G C Koomen; L Arisz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Blood purification     Volume:  10     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  1992  
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  182-8     Citation Subset:  IM    
Department of Medicine, University of Amsterdam, The Netherlands.
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MeSH Terms
Dextrans / pharmacokinetics
Extracellular Space / metabolism
Lymphatic System / metabolism*
Osmolar Concentration
Peritoneal Cavity / physiology
Peritoneal Dialysis, Continuous Ambulatory*
Reg. No./Substance:
0/Solutions; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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