Document Detail

Use of diazepam for hyperemesis gravidarum.
MedLine Citation:
PMID:  19089776     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy and safety of intravenous (IV) fluid and diazepam therapy compared with the IV-fluid only therapy for the resistant hyperemesis gravidarum (HG) cases. METHODS: Medical records of 74 HG cases who were refractory to standard management were reviewed. All patients hospitalised were administered IV fluid and multivitamin combination as the first-step therapy. Patients who were refractory to first-step therapy were given IV fluid (Group 1, n = 43) or IV fluid and diazepam (Group 2, n = 31) depending on the patients' desire. Groups were matched for demographic characteristics, rehospitalisation requirement, patient satisfaction and neonatal outcomes. RESULTS: Thirteen of the 74 patients were excluded from the study because of unknown maternal and fetal outcome. The mean gestational age was 10.4 +/- 2.4 year. Age, parity, body mass index and educational level were similar between the two groups. Mean diazepam dose was 62.8 +/- 24.5 mg (range 40-160) in Group 2 (n = 31). The number of hospitalisation was significantly lower, and patient satisfaction was significantly higher in Group 2. There were no differences for the obstetrics outcomes between the groups. CONCLUSIONS: The addition of diazepam to IV fluids was associated with less hospitalisation in women with hyperemesis gravidarum. Safety of diazepam therapy in early pregnancy deserves further study.
Yasemin Tasci; Berfu Demir; Serdar Dilbaz; Ali Haberal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  22     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-29     Completed Date:  2009-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Ministry of Health, Ankara Etlik Maternity and Women's Health Research Hospital, Etlik, Ankara 06010, Turkey.
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MeSH Terms
Antiemetics / administration & dosage*,  adverse effects
Diazepam / administration & dosage*,  adverse effects
Glucose / administration & dosage
Hyperemesis Gravidarum / drug therapy*
Infusions, Intravenous
Isotonic Solutions / administration & dosage
Sodium Chloride / administration & dosage
Vitamins / administration & dosage
Young Adult
Reg. No./Substance:
0/Antiemetics; 0/Isotonic Solutions; 0/Vitamins; 439-14-5/Diazepam; 50-99-7/Glucose; 7647-14-5/Sodium Chloride; 8022-63-7/Ringer's lactate

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