| Use of deferiprone for the treatment of hepatic iron storage disease in three hornbills. | |
| | |
MedLine Citation:
|
PMID: 22171759 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Case Description-3 hornbills (2 Papua hornbills [Aceros plicatus] and 1 longtailed hornbill [Tockus albocristatus]) were evaluated because of general listlessness and loss of feather glossiness. Clinical Findings-Because hepatic iron storage disease was suspected, liver biopsy was performed and formalin-fixed liver samples were submitted for histologic examination and quantitative image analysis (QIA). Additional frozen liver samples were submitted for chemical analysis. Birds also underwent magnetic resonance imaging (MRI) under general anesthesia for noninvasive measurement of liver iron content. Serum biochemical analysis and analysis of feed were also performed. Results of diagnostic testing indicated that all 3 hornbills were affected with hepatic iron storage disease. Treatment and Outcome-The iron chelator deferiprone was administered (75 mg/kg [34.1 mg/lb], PO, once daily for 90 days). During the treatment period, liver biopsy samples were obtained at regular intervals for QIA and chemical analysis of the liver iron content and follow-up MRI was performed. In all 3 hornbills, a rapid and large decrease in liver iron content was observed. All 3 methods for quantifying the liver iron content were able to verify the decrease in liver iron content. Clinical Relevance-Orally administered deferiprone was found to effectively reduce the liver iron content in these 3 hornbills with iron storage disease. All 3 methods used to monitor the liver iron content (QIA, chemical analysis of liver biopsy samples, and MRI) had similar results, indicating that all of these methods should be considered for the diagnosis of iron storage disease and monitoring of liver iron content during treatment. |
| | |
Authors:
|
Peter Sandmeier; Marcus Clauss; Olivio F Donati; Koen Chiers; Ellen Kienzle; Jean-Michel Hatt |
Related Documents
:
|
11870479 - Radiation dose in dental radiology. 11177739 - Virtual colonoscopy: a novel imaging modality for colorectal cancer. 21879909 - Blast-related traumatic brain injury in u.s. military personnel. 15170789 - Radiation dose in multidetector row computed tomography cardiac imaging. 17457809 - Imaging strategies to reduce the risk of radiation in ct studies, including selective s... 16862419 - Conventional and ct angiography in children: dosimetry and dose comparisons. 18671289 - Anomalies of ulnar nerve conduction in different carpal tunnel syndrome stages. 18164989 - Quantitative morphology of facial nerve based on three-dimensional reconstruction of te... 17623889 - Mri of tumor angiogenesis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American Veterinary Medical Association Volume: 240 ISSN: 1943-569X ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
|
Languages: eng Pagination: 75-81 Citation Subset: IM |
Affiliation:
|
Kleintier- und Vogelpraxis, Tafernstrasse 11b, 5405 Baden-Dättwil, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Use of magnetic resonance imaging and histopathologic findings for diagnosis of an aneurysmal bone c...
Next Document: Conservative management of a transverse fracture of the distal phalanx in a Quarter Horse.