| Use of decrease in apparent diffusion coefficient values to predict infarct age. | |
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MedLine Citation:
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PMID: 20449761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the study was to determine the ability to predict infarct age based on decrease in apparent diffusion coefficient (ADC) values. We retrospectively identified 94 individuals (age range 16 years to 91 years; mean 63.7 + 14.1 years) who underwent magnetic resonance diffusion-weighted imaging at our institution over a course of 14 months whose infarct age could be reliably determined within 1 h. A single observer measured ADC values within the center of the infarct and compared them against values in contralateral normal tissue. We examined the ability of four ADC decrease thresholds (i.e., >50%, >40%, >30%, and >20%) to predict infarct age of <24 and <48 h. Levels of ADC decrease in infarcts were as follows: <20%, n = 9; 20-29%, n = 21; 30-39%, n = 25; 40-49%, n = 23; >50%, n = 16. For prediction of infarct age <24 h, sensitivity for the four ADC decrease thresholds ranged from 25% to 94%, specificity ranged from 10% to 85%, positive predictive value (PPV) ranged from 18% to 25%, and negative predictive value (NPV) ranged from 85% to 89%. For prediction of infarct age <48 h, sensitivity ranged from 23% to 98%, specificity ranged from 15% to 87%, PPV ranged from 46% to 56%, and NPV ranged from 60% to 89%. Test performance characteristics for predicting infarct age of <24 and <48 h were relatively poor. In particular, PPV was very low for predicting infarcts <24 h old. |
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Authors:
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James M Provenzale; Sandra S Stinnett; Stefan T Engelter |
Publication Detail:
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Type: Journal Article Date: 2010-05-07 |
Journal Detail:
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Title: Emergency radiology Volume: 17 ISSN: 1438-1435 ISO Abbreviation: Emerg Radiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431227 Medline TA: Emerg Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 391-5 Citation Subset: IM |
Affiliation:
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Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. prove001@mc.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Aged Aged, 80 and over Brain Infarction / diagnosis* Diffusion Diffusion Magnetic Resonance Imaging / methods* False Positive Reactions Female Humans Male Middle Aged Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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