Document Detail


Use of cytomegalovirus immunoglobulin in multiply transfused premature neonates.
MedLine Citation:
PMID:  7715987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We undertook a randomized, placebo-controlled, double blind trial of cytomegalovirus (CMV) immunoglobulin (CMVIG) for prevention of CMV-associated disease in 183 multiply transfused, premature neonates. CMVIG (150 mg/kg) or placebo was given within 24 hours of the first transfusion and at Day 10. If an intravenous catheter was still in place an additional dose was given between Days 20 and 30. The globulin and placebo groups were well-matched with respect to birth weight, gestational age, Apgar score, birth to a CMV-seropositive mother, requirement for assisted ventilation and exposure to CMV-positive, unscreened blood products. Among infants followed for more than 10 days, 18 (10.5%) developed CMV infection; 9 had symptomatic CMV disease (5 placebo; 4 CMVIG). Among infants born to a CMV-seropositive mother, CMVIG use was associated with a CMV syndrome rate of 3.2% (95% confidence interval, 0.2 to 18.5%) compared to 12.5% (95% confidence interval, 4.5 to 27.6%) among placebo recipients (P = 0.163). Among placebo recipients infants born to CMV-seropositive mothers were more likely to have a virologically confirmed CMV syndrome than those born to a CMV-seronegative mother, despite receipt of blood not screened for CMV antibody (P = 0.012). Multivariate analysis demonstrated that two factors were independently associated with CMV acquisition: the volume of CMV-seropositive blood products transfused (P = 0.005); and birth to a CMV-seropositive mother (P = 0.006). Infusions of CMVIG were well-tolerated. This study reaffirms that perinatally acquired CMV disease is more common among infants born to CMV-seropositive mothers than CMV-seronegative mothers, even without use of CMV-screened blood products.
Authors:
D R Snydman; B G Werner; H C Meissner; S H Cheeseman; J Schwab; F Bednarek; J L Kennedy; M Herschel; A Magno; M J Levin
Related Documents :
9376007 - Vertical transmission of a citrobacter infection.
22772167 - Rash, hepatotoxicity and hyperbilirubinemia among kenyan infants born to hiv-infected w...
724317 - Control of nosocomial respiratory syncytial viral infections.
9091017 - Maternal fever in term labour in relation to fetal tachycardia, cord artery acidaemia a...
16499527 - The impact of parity on course of labor in a contemporary population.
21138827 - A population-based survey of neonaticides using judicial data.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  14     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-18     Completed Date:  1995-05-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  34-40     Citation Subset:  IM    
Affiliation:
Department of Medicine, New England Medical Center, Boston, MA 02111, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / administration & dosage*
Blood Transfusion / adverse effects*
Child, Preschool
Cytomegalovirus / immunology*
Cytomegalovirus Infections / prevention & control*
Double-Blind Method
Female
Humans
Infant, Newborn
Infant, Premature, Diseases / prevention & control*
Male
Maternal-Fetal Exchange
Placebos
Pregnancy
Risk Factors
Grant Support
ID/Acronym/Agency:
HL 29883/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Placebos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An epidemic of aplastic crisis caused by human parvovirus B19.
Next Document:  Serial serum C-reactive protein to monitor recovery from acute hematogenous osteomyelitis in childre...