| Use of cytokines in clozapine-induced agranulocytosis. | |
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MedLine Citation:
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PMID: 8793147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report and review the use of cytokines for the treatment of clozapine-induced neutropenia. METHOD: Case report and review of literature. RESULTS: Cytokines, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), appear to shorten the duration of clozapine-induced neutropenia. CONCLUSIONS: G-CSF or GM-CSF therapy should be considered in patients with profound neutropenia of prolonged duration (high-risk neutropenia). |
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Authors:
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I Chin-Yee; K Bezchlibnyk-Butler; L Wong |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Canadian journal of psychiatry. Revue canadienne de psychiatrie Volume: 41 ISSN: 0706-7437 ISO Abbreviation: Can J Psychiatry Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2007-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7904187 Medline TA: Can J Psychiatry Country: CANADA |
Other Details:
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Languages: eng Pagination: 280-4 Citation Subset: IM |
Affiliation:
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Department of Hematology, London Health Sciences Centre, Ontario. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Agranulocytosis / chemically induced*, therapy Antipsychotic Agents / adverse effects*, therapeutic use Clozapine / adverse effects*, therapeutic use Granulocyte Colony-Stimulating Factor / administration & dosage* Granulocytes / drug effects Humans Injections, Subcutaneous Leukocyte Count / drug effects Male Neutropenia / chemically induced, therapy Schizophrenia / drug therapy* Schizophrenic Psychology* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 143011-72-7/Granulocyte Colony-Stimulating Factor; 5786-21-0/Clozapine |
| Comments/Corrections | |
Comment In:
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Can J Psychiatry. 1996 Nov;41(9):603
[PMID:
8946085
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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