Document Detail


Use of current generation perfluorocarbon emulsions in cardiac surgery.
MedLine Citation:
PMID:  7849969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of novel perfluorocarbon emulsions that contain higher concentrations of perfluorochemicals than previous emulsions has renewed interest in the use of this class of erythrocyte substitute in cardiopulmonary bypass (CPB). Perfluorocarbons have the potential to increase the oxygen content of the perfusate and thus increase the capacity of the heart-lung machine to deliver oxygen to the body during CPB. Increasing the capacity of the heart-lung machine to deliver oxygen to the body has important implications for the conduct of cardiac operations. For example, adding perfluorocarbons to the pump prime solution may allow larger volumes of blood to be withdrawn from the patient immediately prior to bypass for transfusion after bypass. Lowering the acceptable hematocrit during CPB with the use of perfluorocarbons may also decrease the need for homologous transfusions of erythrocytes in neonates or anemic adults who undergo CPB.
Authors:
W L Holman; D C McGiffin; W V Vicente; R D Spruell; A D Pacifico
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  22     ISSN:  1073-1199     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  979-90     Citation Subset:  IM    
Affiliation:
Division of Cardiothoracic Surgery, University of Alabama at Birmingham.
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MeSH Terms
Descriptor/Qualifier:
Blood Substitutes / pharmacology*
Cardiac Surgical Procedures*
Cardiopulmonary Bypass
Clinical Trials as Topic
Emulsions
Fluorocarbons / therapeutic use*
Humans
Pilot Projects
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Emulsions; 0/Fluorocarbons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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