| Use of current generation perfluorocarbon emulsions in cardiac surgery. | |
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MedLine Citation:
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PMID: 7849969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of novel perfluorocarbon emulsions that contain higher concentrations of perfluorochemicals than previous emulsions has renewed interest in the use of this class of erythrocyte substitute in cardiopulmonary bypass (CPB). Perfluorocarbons have the potential to increase the oxygen content of the perfusate and thus increase the capacity of the heart-lung machine to deliver oxygen to the body during CPB. Increasing the capacity of the heart-lung machine to deliver oxygen to the body has important implications for the conduct of cardiac operations. For example, adding perfluorocarbons to the pump prime solution may allow larger volumes of blood to be withdrawn from the patient immediately prior to bypass for transfusion after bypass. Lowering the acceptable hematocrit during CPB with the use of perfluorocarbons may also decrease the need for homologous transfusions of erythrocytes in neonates or anemic adults who undergo CPB. |
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Authors:
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W L Holman; D C McGiffin; W V Vicente; R D Spruell; A D Pacifico |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 22 ISSN: 1073-1199 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 1994 |
Date Detail:
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Created Date: 1995-03-16 Completed Date: 1995-03-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 979-90 Citation Subset: IM |
Affiliation:
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Division of Cardiothoracic Surgery, University of Alabama at Birmingham. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Substitutes
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pharmacology* Cardiac Surgical Procedures* Cardiopulmonary Bypass Clinical Trials as Topic Emulsions Fluorocarbons / therapeutic use* Humans Pilot Projects |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Emulsions; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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