Document Detail

Use of corticosteriods in the prevention of post-ERCP pancreatitis: results of a controlled prospective study.
MedLine Citation:
PMID:  10201469     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this prospective controlled study was to determine whether prophylactic corticosteroids decrease the incidence of post-ERCP pancreatitis. METHODS: A double-blind comparison of hydrocortisone (100 mg by i.v. infusion immediately before endoscopy) with placebo (sodium chloride administered in the same fashion). A total of 535 patients (286 women and 249 men, with an average age of 58.6 yr) who were scheduled to undergo diagnostic or operative ERCP underwent randomization. Six patients were excluded from the final evaluation for various reasons. The remaining 529 patients, 263 in the hydrocortisone group and 266 in the placebo group, were analyzed. Patients were divided into subgroups with regard to high risk factors for acute pancreatitis after ERCP. RESULTS: The overall incidence of acute pancreatitis was 5.3% (28 of 529 patients). Procedure-induced pancreatitis occurred in 15 of 263 (5.7%) patients treated with hydrocortisone and in 13 of 266 (4.9%) patients treated with placebo (p = NS). The results of analysis of risk factors for pancreatitis did not evidence any significant difference between the hydrocortisone group and the placebo group. CONCLUSIONS: Hydrocortisone does not prevent acute pancreatitis after diagnostic or therapeutic ERCP.
G D De Palma; C Catanzano
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  94     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-04-29     Completed Date:  1999-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  982-5     Citation Subset:  IM    
Servizio Centralizzato Di Endoscopia Digestiva Operatoria, University of Naples Federico II, Italy.
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MeSH Terms
Acute Disease
Anti-Inflammatory Agents / therapeutic use*
Cholangiopancreatography, Endoscopic Retrograde / adverse effects*
Double-Blind Method
Hydrocortisone / therapeutic use*
Middle Aged
Pancreatitis / epidemiology,  etiology,  prevention & control*
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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