Document Detail

Use of a cloned gene involved in candicidin production to discover new polyene producer Streptomyces strains.
MedLine Citation:
PMID:  2397878     Owner:  NLM     Status:  MEDLINE    
A p-aminobenzoic synthase gene (pabS) from Streptomyces griseus IMRU 3570 involved in candicidin production was used as probe to find new aromatic polyene producing Streptomyces strains. The pab gene hybridizes with 6 out of 16 Streptomyces strains, and those strains which hybridize turned out to be polyene producers. Such strains were never before described as polyene producers.
J A Gil; L M Criado; T Alegre; J F Martín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEMS microbiology letters     Volume:  58     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-10-18     Completed Date:  1990-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  15-8     Citation Subset:  IM    
Area de Microbiologia, Facultad de Biología, Universidad de León, Spain.
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MeSH Terms
Anti-Bacterial Agents / biosynthesis*
Blotting, Southern
Candicidin / biosynthesis*
Cloning, Molecular
DNA, Bacterial
Genes, Bacterial
Restriction Mapping
Streptomyces / genetics*,  metabolism
Transaminases / genetics*
Transformation, Bacterial
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/DNA, Bacterial; 1403-17-4/Candicidin; EC 2.6.1.-/PABA synthase; EC 2.6.1.-/Transaminases

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