Document Detail

Use of ciprofloxacin as a prophylactic agent in urinary tract infections in renal transplant recipients.
MedLine Citation:
PMID:  9361939     Owner:  NLM     Status:  MEDLINE    
The most common form of bacterial infection in renal transplant recipients is urinary tract infection (UTI), and some studies have shown that prophylaxis can reduce this incidence. In the present investigation we evaluated 80 patients submitted to renal transplantation at the Renal Transplant Unit of the University Hospital of Ribeirao Preto, SP. The study was prospective, double blind and randomized. The patients were divided into two groups, one receiving placebo and the other ciprofloxacin at the dose of 250 mg twice a day for the first 10 d and 250 mg/d for 6 months after transplantation. Of the 41 patients who received ciprofloxacin 28 completed the study, and of the 39 patients who received placebo 30 completed the study. The largest number of UTI occurred in the placebo group, with a significant difference from the ciprofloxacin group during the first month after surgery (p < 0.05). In the group treated with ciprofloxacin, only 6/40 patients (15%) developed UTI, as opposed to 19/39 (48.7%) for the placebo group. The total number of infectious episodes was higher in the placebo group (26) than in the ciprofloxacin group (12). The medication was well tolerated throughout the study period.
M Moysés Neto; R S Costa; M A Reis; A S Ferraz; L T Saber; M E Batista; V Muglia; T M Garcia; J F Figueiredo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical transplantation     Volume:  11     ISSN:  0902-0063     ISO Abbreviation:  Clin Transplant     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-26     Completed Date:  1998-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8710240     Medline TA:  Clin Transplant     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  446-52     Citation Subset:  IM    
Department of Nephrology, Hospital das Clínicas, Faculty of Medicine of Ribeirao Preto, University of São Paulo, Brazil.
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MeSH Terms
Administration, Oral
Anti-Infective Agents / administration & dosage,  adverse effects,  therapeutic use*
Bacteriuria / prevention & control
Candidiasis / etiology,  prevention & control
Cause of Death
Ciprofloxacin / administration & dosage,  adverse effects,  therapeutic use*
Double-Blind Method
Follow-Up Studies
Kidney Transplantation*
Middle Aged
Prospective Studies
Urinary Tract Infections / etiology,  prevention & control*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Placebos; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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