Document Detail


Use of chromogenic assay of factor X to accept or reject INR results in Warfarin treated patients.
MedLine Citation:
PMID:  19625497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A warfarin treated patient unexpectedly presented with an elevated international normalized ratio (INR). Repeat testing in two laboratories gave conflicting results. The chromogenic assay of factor X was used to determine the correct INR result. The patient had laboratory results consistent with a dysfibrinogenemia, which prevented detection of the endpoint with a photo-optical detection system. The chromogenic assay of factor X is recommended for monitoring patients on warfarin when the INR cannot be accurately determined due to interference with the fibrin endpoint in the INR.
Authors:
Michael J Sanfelippo; Wendy Zinsmaster; Doris L Scherr; Gene R Shaw
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-07-22
Journal Detail:
Title:  Clinical medicine & research     Volume:  7     ISSN:  1554-6179     ISO Abbreviation:  Clin Med Res     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-06     Completed Date:  2009-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101175887     Medline TA:  Clin Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-5     Citation Subset:  IM    
Affiliation:
Coagulation Services, Marshfield Labs, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA. sanfelippo.michael@marshfieldclinic.org
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MeSH Terms
Descriptor/Qualifier:
Aged
Anticoagulants / therapeutic use*
Blood Coagulation / drug effects
Chromogenic Compounds
Factor X / metabolism*
Female
Fibrin / chemistry*
Fibrinogen / immunology
Heart Failure / complications
Humans
International Normalized Ratio*
Lung Neoplasms / complications,  surgery
Prothrombin Time
Time Factors
Warfarin / therapeutic use*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Chromogenic Compounds; 81-81-2/Warfarin; 9001-29-0/Factor X; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen
Comments/Corrections

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