Document Detail

Use of chromogenic assay of factor X to accept or reject INR results in Warfarin treated patients.
MedLine Citation:
PMID:  19625497     Owner:  NLM     Status:  MEDLINE    
A warfarin treated patient unexpectedly presented with an elevated international normalized ratio (INR). Repeat testing in two laboratories gave conflicting results. The chromogenic assay of factor X was used to determine the correct INR result. The patient had laboratory results consistent with a dysfibrinogenemia, which prevented detection of the endpoint with a photo-optical detection system. The chromogenic assay of factor X is recommended for monitoring patients on warfarin when the INR cannot be accurately determined due to interference with the fibrin endpoint in the INR.
Michael J Sanfelippo; Wendy Zinsmaster; Doris L Scherr; Gene R Shaw
Related Documents :
22906277 - 4-1bb ligand-mediated imbalance of helper 17 t cells and regulatory t cells in patients...
3106577 - Factor viii r:ag as a prognostic parameter in intracranial haemorrhage.
21939827 - Characterization of clopidogrel hypersensitivity reactions and management with oral ste...
7555437 - Prothrombotic state and signs of endothelial lesion in plasma of patients with inflamma...
1580447 - Prediction of steroid responsiveness in the idiopathic nephrotic syndrome using urinary...
24259117 - Multiple sclerosis : a multielement survey.
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-07-22
Journal Detail:
Title:  Clinical medicine & research     Volume:  7     ISSN:  1554-6179     ISO Abbreviation:  Clin Med Res     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-06     Completed Date:  2009-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101175887     Medline TA:  Clin Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-5     Citation Subset:  IM    
Coagulation Services, Marshfield Labs, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anticoagulants / therapeutic use*
Blood Coagulation / drug effects
Chromogenic Compounds
Factor X / metabolism*
Fibrin / chemistry*
Fibrinogen / immunology
Heart Failure / complications
International Normalized Ratio*
Lung Neoplasms / complications,  surgery
Prothrombin Time
Time Factors
Warfarin / therapeutic use*
Reg. No./Substance:
0/Anticoagulants; 0/Chromogenic Compounds; 81-81-2/Warfarin; 9001-29-0/Factor X; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 a...
Next Document:  Rapunzel syndrome: a comprehensive review of an unusual case of trichobezoar.