| Use of chromogenic assay of factor X to accept or reject INR results in Warfarin treated patients. | |
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MedLine Citation:
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PMID: 19625497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A warfarin treated patient unexpectedly presented with an elevated international normalized ratio (INR). Repeat testing in two laboratories gave conflicting results. The chromogenic assay of factor X was used to determine the correct INR result. The patient had laboratory results consistent with a dysfibrinogenemia, which prevented detection of the endpoint with a photo-optical detection system. The chromogenic assay of factor X is recommended for monitoring patients on warfarin when the INR cannot be accurately determined due to interference with the fibrin endpoint in the INR. |
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Authors:
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Michael J Sanfelippo; Wendy Zinsmaster; Doris L Scherr; Gene R Shaw |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-07-22 |
Journal Detail:
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Title: Clinical medicine & research Volume: 7 ISSN: 1554-6179 ISO Abbreviation: Clin Med Res Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-06 Completed Date: 2009-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101175887 Medline TA: Clin Med Res Country: United States |
Other Details:
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Languages: eng Pagination: 103-5 Citation Subset: IM |
Affiliation:
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Coagulation Services, Marshfield Labs, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA. sanfelippo.michael@marshfieldclinic.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticoagulants / therapeutic use* Blood Coagulation / drug effects Chromogenic Compounds Factor X / metabolism* Female Fibrin / chemistry* Fibrinogen / immunology Heart Failure / complications Humans International Normalized Ratio* Lung Neoplasms / complications, surgery Prothrombin Time Time Factors Warfarin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Chromogenic Compounds; 81-81-2/Warfarin; 9001-29-0/Factor X; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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