Document Detail


Use of a chlorhexidine-impregnated patch does not decrease the incidence of bacterial colonization of femoral nerve catheters: a randomized trial.
MedLine Citation:
PMID:  22855310     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Femoral nerve catheter (FNC) insertion is commonly performed for postoperative analgesia following total knee arthroplasty (TKA). A wide range of rates has been reported relating to the bacterial colonization of catheters complicating FNC insertion. The BIOPATCH® is a chlorhexidine (CHG) impregnated patch designed to inhibit bacterial growth for days. The BIOPATCH has proven to be effective at decreasing bacterial colonization in epidural and vascular catheters. We hypothesized that the BIOPATCH would be effective at decreasing the rates of FNC bacterial colonization.
METHODS: Following Institutional Review Board approval and written informed consent, 100 patients scheduled for TKA were prospectively enrolled in the study. Patients at elevated risk for infection were excluded from analysis. Femoral nerve catheters were inserted and tunneled under sterile conditions using ultrasound guidance following CHG skin cleansing. Participants were then randomized either to have the BIOPATCH applied to the catheter exit site or not to have the patch applied. All patients received pre/postoperative antibiotic therapy. The FNC tip and catheter exit site were cultured for bacterial growth at the conclusion of therapy.
RESULTS: No differences were observed between groups in regards to catheter exit site. Catheter colonization was observed in three of 48 (6.3%) BIOPATCH patients and two of 47 (4.3%) non-BIOPATCH patients (risk ratio [RR] = 1.5; 95% confidence interval [CI] 0.3 to 8.4; P = 1.0). Colonization of the catheter exit site was observed in 12 BIOPATCH and 14 non-BIOPATCH patients (RR = 0.8; 95% CI 0.4 to 1.6; P = 0.65). Local skin inflammation (non-BIOPATCH 10.6% vs BIOPATCH 2.1%) and colonization of the FNC exit site by more than one type of bacteria trended towards increased values in the non-BIOPATCH group.
CONCLUSIONS: The baseline rate of bacterial colonization of FNCs is quite low in the setting of short-term use, CHG skin decontamination, ultrasound guidance, subcutaneous tunneling, and perioperative antibiotic therapy. No benefit was shown by using the BIOPATCH in this patient population. (ClinicalTrials.gov number: NCT01411891).
Authors:
Kristopher M Schroeder; Robert A Jacobs; Christopher Guite; Kyle Gassner; Brooke Anderson; Melanie J Donnelly
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-08-02
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  59     ISSN:  1496-8975     ISO Abbreviation:  Can J Anaesth     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-11     Completed Date:  2013-02-13     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  950-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, Madison, WI 53792, USA. kmschro1@wisc.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01411891
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Bacterial Agents / therapeutic use
Anti-Infective Agents, Local / administration & dosage,  pharmacology*
Arthroplasty, Replacement, Knee / methods*
Bandages
Catheter-Related Infections / microbiology,  prevention & control*
Catheterization / methods
Chlorhexidine / administration & dosage,  pharmacology*
Female
Femoral Nerve
Humans
Male
Middle Aged
Prospective Studies
Ultrasonography, Interventional
Grant Support
ID/Acronym/Agency:
1UL1RR025011/RR/NCRR NIH HHS; UL1 RR025011/RR/NCRR NIH HHS; UL1 TR000427/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents, Local; 55-56-1/Chlorhexidine
Comments/Corrections
Comment In:
Can J Anaesth. 2013 Jan;60(1):87-8   [PMID:  23264009 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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