Document Detail

Use of a chitosan-based hemostatic dressing in laparoscopic partial nephrectomy.
MedLine Citation:
PMID:  17932955     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: An external chitosan-based hemostatic bandage has been used to control aggressive bleeding from traumatic injuries. This study was to evaluate the feasibility of using an internal chitosan dressing based on the external platform to control hemorrhage and urinary leakage by sealing off the parenchymal wound following Laparoscopic partial nephrectomy (LPN) in a porcine model. METHODS: Nine heparinized domestic swine underwent bilateral laparoscopic partial nephrectomies involving either a polar (N = 13) or wedge resection (N = 5) followed by treatment with the chitosan dressing. Estimated blood loss, hemostatic score, urinary leakage, operative time, and adhesion score of the chitosan dressing were recorded. RESULTS: Of the 18 procedures, 17 achieved complete hemostasis after deployment of the chitosan dressing. The hemostasis score improved significantly after the deployment in both polar (p < 0.001) and wedge (p = 0.017) resections. The rate of successful pyelocaliceal sealing was 85% (11/13) in polar resections and 60% (3/5) in wedge resections. CONCLUSION: The chitosan-based hemostatic dressing is effective as a primary or supplemental material for controlling parenchymal hemorrhage and sealing the renal collecting system following LPN in the animal model.
Hua Xie; Yashodhan S Khajanchee; Jeffrey S Teach; Brian S Shaffer
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  85     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
Oregon Medical Laser Center, Providence St. Vincent Medical Center, Portland, Oregon, USA.
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MeSH Terms
Biocompatible Materials / chemistry,  therapeutic use
Chitosan* / chemistry,  therapeutic use
Hemorrhage / therapy*
Hemostatic Techniques*
Hemostatics* / chemistry,  therapeutic use
Materials Testing
Sus scrofa
Grant Support
R41 DK072559-01/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Biocompatible Materials; 0/Hemostatics; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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