| Use of chitosan-alginate as alternative pelletization aid to microcrystalline cellulose in extrusion/spheronization. | |
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MedLine Citation:
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PMID: 17286294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two types of different molecular weight chitosan were investigated as a pelletization aid in extrusion/spheronization using water as granulation liquid. Spherical pellets with a maximum fraction of 60% w/w chitosan could be produced when 1.25-2.5% w/w sodium alginate was included in the formulations with no microcrystalline cellulose (MCC). Chitosan with lower molecular weight of 190 kDa showed a better pellet forming property. The pellets obtained had acceptable physical characteristics and a fast drug release. The results from Fourier transform infrared spectroscopy, differential scanning calorimetry and (13)C CP-MAS nuclear magnetic resonance spectroscopy confirmed the formation of polyelectrolyte complex (PEC) between chitosan and sodium alginate, which might be a reason for successful pelletization by extrusion/spheronization. Moreover, the presence of PEC might influence the physical characteristics and dissolution behavior of chitosan-alginate pellets. The results indicated an achievement in production of pellets by extrusion/spheronization without using MCC. Moreover, chitosan combined with sodium alginate could be used as a promising alternative pelletization aid to MCC in extrusion/spheronization. |
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Authors:
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Nattawut Charoenthai; Peter Kleinebudde; Satit Puttipipatkhachorn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 96 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-02 Completed Date: 2007-11-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2469-84 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association. |
Affiliation:
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Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Sri-Ayudhya Road, Bangkok 10400, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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administration & dosage,
chemistry Alginates / chemistry* Cellulose / chemistry* Chemistry, Pharmaceutical Chemistry, Physical Chitosan / chemistry* Drug Compounding Excipients / chemistry* Hardness Image Processing, Computer-Assisted Molecular Weight Particle Size Physicochemical Phenomena Viscosity Water / analysis |
| Chemical | |
Reg. No./Substance:
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0/Alginates; 0/Excipients; 0/microcrystalline cellulose; 103-90-2/Acetaminophen; 7732-18-5/Water; 9004-34-6/Cellulose; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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