Document Detail

Use of the chiral pharmaceutical propranolol to identify sewage discharges into surface waters.
MedLine Citation:
PMID:  16382949     Owner:  NLM     Status:  MEDLINE    
The discharge of relatively small volumes of untreated sewage is a source of wastewater-derived contaminants in surface waters that is often ignored because it is difficult to discriminate from wastewater effluent. To identify raw sewage discharges, we analyzed the two enantiomers of the popular chiral pharmaceutical, propranolol, after derivitization to convert the enantiomers to diastereomers. The enantiomeric fraction (the ratio of the concentration of one of its isomers to the total concentration) of propranolol in the influent of five wastewater treatment plants was 0.50 +/- 0.02, while after secondary treatment it was 0.42 or less. In a laboratory study designed to simulate an activated sludge municipal wastewater treatment system, the enantiomeric fraction of propranolol decreased from 0.5 to 0.43 as the compound underwent biotransformation. In a similar system designed to simulate an effluent-dominanted surface water, the enantiomeric fraction of propranolol remained constant as it underwent biotransformation. Analysis of samples from surface waters with known or suspected discharges of untreated sewage contained propranolol with an enantiomeric fraction of approximately 0.50 whereas surface waters with large discharges of wastewater effluent contained propranolol with enantiomeric fractions similar to those observed in wastewater effluent. Measurement of enantiomers of propranolol may be useful in detecting and documenting contaminants related to leaking sewers and combined sewer overflows.
Lorien J Fono; David L Sedlak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental science & technology     Volume:  39     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-30     Completed Date:  2006-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9244-52     Citation Subset:  IM    
Department of Civil and Environmental Engineering, University of California, Berkeley 94720, USA.
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MeSH Terms
Chromatography, Gas
Propranolol / chemistry*
Water Pollutants*
Reg. No./Substance:
0/Sewage; 0/Water Pollutants; 525-66-6/Propranolol
Comment In:
Environ Sci Technol. 2005 Dec 1;39(23):474A   [PMID:  16382913 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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