| Use of chemosensitization to overcome fludioxonil resistance in Penicillium expansum. | |
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MedLine Citation:
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PMID: 20536709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To overcome fludioxonil resistance of Penicillium expansum, a mycotoxigenic fungal pathogen causing postharvest decay in apple, by using natural phenolic chemosensitizing agents. METHODS AND RESULTS: Fludioxonil-resistant mutants of P. expansum were co-treated with different oxidising and natural phenolic agents. Resistance was overcome by natural phenolic chemosensitizing agents targeting the oxidative stress-response pathway. These agents also augmented effectiveness of the fungicide, kresoxim-methyl. Results indicated that alkyl gallates target mitochondrial respiration and/or its antioxidation system. Fungal mitochondrial superoxide dismutase (Mn-SOD) plays a protective role against alkyl gallates. CONCLUSIONS: Natural chemosensitizing agents targeting the oxidative stress-response system, such as Mn-SOD, can synergize commercial fungicides. SIGNIFICANCE AND IMPACT OF THE STUDY: Redox-active compounds can serve as potent chemosensitizing agents to overcome resistance and lower effective dosages of fungicides. This can reduce costs with coincidental lowering of environmental and health risks. |
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Authors:
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J H Kim; B C Campbell; N Mahoney; K L Chan; R J Molyneux; C L Xiao |
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Publication Detail:
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Type: Journal Article Date: 2010-05-22 |
Journal Detail:
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Title: Letters in applied microbiology Volume: 51 ISSN: 1472-765X ISO Abbreviation: Lett. Appl. Microbiol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510094 Medline TA: Lett Appl Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 177-83 Citation Subset: IM |
Affiliation:
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Plant Mycotoxin Research Unit, Western Regional Research Center, USDA-ARS, Albany, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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pharmacology* Dioxoles / pharmacology* Drug Interactions Drug Resistance, Fungal / drug effects* Fungal Proteins / metabolism Malus / microbiology Metabolic Networks and Pathways / drug effects Methacrylates / pharmacology Mitochondria / drug effects Mitochondrial Proteins / metabolism Oxidants / pharmacology* Oxidative Stress* Penicillium / drug effects*, isolation & purification Phenols / pharmacology* Phenylacetates / pharmacology Pyrroles / pharmacology* Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Dioxoles; 0/Fungal Proteins; 0/Methacrylates; 0/Mitochondrial Proteins; 0/Oxidants; 0/Phenols; 0/Phenylacetates; 0/Pyrroles; 0/kresoxim-methyl; 131341-86-1/fludioxonil; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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