Document Detail

Use of changes in B-type natriuretic peptides to detect ischemia in selected patients.
MedLine Citation:
PMID:  18632168     Owner:  NLM     Status:  In-Process    
BACKGROUND: There is accumulating evidence that transient exercise-induced ischemia triggers the release of B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP). The aim of this study was to either confirm or refute a previous investigation suggesting that myocardial ischemia can reliably be detected by exercise-induced changes in BNP or NT-proBNP levels in selected patients. METHODS: A total of 139 consecutive patients with normal left ventricular function and normal resting BNP and NT-proBNP levels referred for rest/stress myocardial perfusion single-photon emission computed tomography (SPECT) were analyzed. Levels of BNP and NT-proBNP were determined before and immediately after symptom-limited bicycle ergometry. RESULTS: Inducible myocardial ischemia on perfusion images was detected in 46 patients (33%). Median exercise-induced increases in BNP (DeltaBNP) and NT-proBNP (DeltaNT-proBNP) were similar in patients with and without inducible ischemia (DeltaBNP 12.7 pg/ml vs. 9.4 pg/ml, p=0.109; DeltaNT-proBNP 7 pg/ml vs. 6 pg/ml, p=0.309). The area under the receiver operating characteristic curve for the ability to detect myocardial ischemia was 0.583 (95% CI, 0.479-0.688) for DeltaBNP, and 0.553 (95% CI, 0.450-0.656) for DeltaNT-proBNP. CONCLUSIONS: Exercise-induced changes in BNP and NT-proBNP do not reliably detect myocardial ischemia in selected patients.
Daniel Staub; Daniel Jauslin; Heike Freidank; Anne Taegtmeyer; Tobias Breidthardt; Michael J Zellweger; Jan Mueller-Brand; Michael Christ; Christian Mueller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-15
Journal Detail:
Title:  International journal of cardiology     Volume:  136     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  40-6     Citation Subset:  IM    
Department of Internal Medicine, University Hospital Basel, Switzerland.
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