| Use of changes in B-type natriuretic peptides to detect ischemia in selected patients. | |
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MedLine Citation:
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PMID: 18632168 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: There is accumulating evidence that transient exercise-induced ischemia triggers the release of B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP). The aim of this study was to either confirm or refute a previous investigation suggesting that myocardial ischemia can reliably be detected by exercise-induced changes in BNP or NT-proBNP levels in selected patients. METHODS: A total of 139 consecutive patients with normal left ventricular function and normal resting BNP and NT-proBNP levels referred for rest/stress myocardial perfusion single-photon emission computed tomography (SPECT) were analyzed. Levels of BNP and NT-proBNP were determined before and immediately after symptom-limited bicycle ergometry. RESULTS: Inducible myocardial ischemia on perfusion images was detected in 46 patients (33%). Median exercise-induced increases in BNP (DeltaBNP) and NT-proBNP (DeltaNT-proBNP) were similar in patients with and without inducible ischemia (DeltaBNP 12.7 pg/ml vs. 9.4 pg/ml, p=0.109; DeltaNT-proBNP 7 pg/ml vs. 6 pg/ml, p=0.309). The area under the receiver operating characteristic curve for the ability to detect myocardial ischemia was 0.583 (95% CI, 0.479-0.688) for DeltaBNP, and 0.553 (95% CI, 0.450-0.656) for DeltaNT-proBNP. CONCLUSIONS: Exercise-induced changes in BNP and NT-proBNP do not reliably detect myocardial ischemia in selected patients. |
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Authors:
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Daniel Staub; Daniel Jauslin; Heike Freidank; Anne Taegtmeyer; Tobias Breidthardt; Michael J Zellweger; Jan Mueller-Brand; Michael Christ; Christian Mueller |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-15 |
Journal Detail:
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Title: International journal of cardiology Volume: 136 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 40-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University Hospital Basel, Switzerland. staubd@uhbs.ch |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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