| Use of a capillary input function with cardiac output for the estimation of lesion pharmacokinetic parameters: preliminary results on a breast cancer patient. | |
| | |
MedLine Citation:
|
PMID: 21346279 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The objective of this work was to propose and demonstrate a novel technique for the assessment of tumour pharmacokinetic parameters together with a regionally estimated vascular input function. A breast cancer patient T2*-weighted dynamic contrast enhanced MRI (DCE-MRI) dataset acquired at high temporal resolution during the first-pass bolus perfusion was used for testing the technique. Extraction of the lesion volume transfer constant K(trans) together with the intravascular plasma volume fraction v(p) was achieved by optimizing a capillary input function with a measure of cardiac output using the principle of intravascular indicator dilution theory. For a region of interest drawn within the breast lesion a v(p) of 0.16 and a K(trans) of 0.70 min(-1) were estimated. Despite the value of v(p) being higher than expected, estimated K(trans) was in accordance with the literature values. In conclusion, the technique proposed here, has the main advantage of allowing the estimation of breast tumour pharmacokinetic parameters from first-pass perfusion T2*-weighted DCE-MRI data without the need of measuring an arterial input function. The technique may also have applicability to T1-weighted DCE-MRI data. |
| | |
Authors:
|
P Di Giovanni; T S Ahearn; S I Semple; C A Azlan; W K C Lloyd; F J Gilbert; T W Redpath |
Related Documents
:
|
2106329 - Acquired factor viii inhibitor with squamous cell cancer of the epiglottis. 21382839 - Relation of fgfr2 genetic polymorphisms to the association between oral contraceptive u... 12605559 - The therapeutic potential of aromatase inhibitors. 15083379 - Aromatase inhibitors: new endocrine treatment of breast cancer. 21512679 - The efficacy of (99m)tc-mibi scintimammography in the evaluation of breast lesions and ... 21440969 - Dead by 50: lay expertise and breast cancer screening. 17700979 - A retrospective study examining the socioeconomic backgrounds of women undergoing bilat... 21115859 - Fasting c-peptide levels and death resulting from all causes and breast cancer: the hea... 7933179 - Urethral involvement in female bladder cancer patients: mapping of 47 consecutive cysto... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
|
Title: Physics in medicine and biology Volume: 56 ISSN: 1361-6560 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: - |
Other Details:
|
Languages: ENG Pagination: 1743-1753 Citation Subset: - |
Affiliation:
|
Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optimization algorithm for overlapping-field plans of scanned ion beam therapy with reduced sensitiv...
Next Document: Comparison of blood velocity measurements between ultrasound Doppler and accelerated phase-contrast ...