Document Detail

Use of buffered lidocaine in bone marrow biopsies: a randomized, controlled trial.
MedLine Citation:
PMID:  19136338     Owner:  NLM     Status:  MEDLINE    
PURPOSE/OBJECTIVES: To determine whether a difference exists in perceived pain during preprocedure anesthetic injection for bone marrow biopsy between buffered and unbuffered lidocaine, to determine whether pain levels change over time, and to investigate relationships between perceived pain scores and other variables. DESIGN: A double-blind, randomized, experimental, crossover design. SETTING: A large hospital in the midwestern region of the United States. SAMPLE: 48 patients undergoing bone marrow biopsy. METHODS: The patients served as their own controls for the bilateral procedure. A 100 mm visual analog scale measured pain. A demographic questionnaire gathered the between-subjects exploratory variables. MAIN RESEARCH VARIABLES: Perceived pain scores and type of lidocaine anesthetic solution (buffered versus unbuffered). FINDINGS: Participants reported significantly lower pain scores on the side anesthetized with buffered lidocaine compared with the side anesthetized with unbuffered lidocaine. Higher pain scores were reported on the treatment side for participants who had received more than two surgical procedures. Patients who were members of a minority group had higher mean pain scores than Caucasians on the control side. CONCLUSIONS: Buffered lidocaine is superior to unbuffered lidocaine as an anesthetic for bone marrow biopsy procedures. IMPLICATIONS FOR NURSING: Advanced practice nurses perform a significant number of bone marrow biopsies and aim to improve patient comfort during invasive procedures. Use of unbuffered lidocaine should be questioned.
Tracy A Ruegg; Christine R Curran; Tammy Lamb
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology nursing forum     Volume:  36     ISSN:  1538-0688     ISO Abbreviation:  Oncol Nurs Forum     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7809033     Medline TA:  Oncol Nurs Forum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-60     Citation Subset:  IM; N    
Ohio State University's Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio, USA.
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MeSH Terms
Aged, 80 and over
Anesthetics, Local / administration & dosage*,  adverse effects
Biopsy / adverse effects*
Bone Marrow Examination* / nursing
Cross-Over Studies
Double-Blind Method
Hematologic Neoplasms / nursing,  pathology
Lidocaine / administration & dosage*,  adverse effects
Middle Aged
Pain / chemically induced,  etiology,  prevention & control*
Pain Measurement
Sodium Bicarbonate / administration & dosage
Young Adult
Reg. No./Substance:
0/Anesthetics, Local; 0/Buffers; 137-58-6/Lidocaine; 144-55-8/Sodium Bicarbonate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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